Description
Obtaining experimental models and characterisation of the effects produced by:
- Systemic and tissue-specific loss/gain of frataxin and paraplegia function in Drosophila.
- Functional alterations of both proteins in humanised paraplegia and frataxin models in Drosophila.
Keywords
Friedreich’s Ataxia, spastic paraplegia type 7, experimental models, drosophila, genome modifiers, drugs, therapeutic targets
Frascati classification
