• Senescence in cerebral ischaemia.
• Autophagy and mitophagy in experimental cerebral ischaemia.
• Ischaemic tolerance and neuroprotection in experimental cerebral ischaemia.
• Inflammatory response and neuroreparation in experimental ischaemic stroke.
• Influence of experimental diabetes on mechanisms regulating vascular reactivity.

• Physiology, physiopathology and musculoskeletal therapeutics

•    Applications of thermography to the study of physical exercise and sport
• Applications of thermography to the study of pathologies involving temperature variation.
• Use of structured light and digital image analysis in the study of the topography of surfaces of medical and sporting interest.
• Influence of physiological movements on medical image analysis.
• Image analysis in biomedicine.
• Physical and clinical dosimetry in Radiotherapy.
• Applications of dynamic speckle in biological processes.

• Fisiopatología y tratamiento de la esclerosis lateral amiotrófica.
• Protección frente al daño inducido por las radiaciones ionizantes: radioprotectores y radiomitigadores.
• Uso de las radiaciones no ionizantes para el tratamiento de cánceres altamente agresivos.
• Efectos anticancerígenos y antiinflamatorios de los polifenoles naturales.

• Role of TLR4 receptors in the neuroinflammatory response associated with alcohol consumption during adolescence.
• Involvement of extracellular vesicles in neuroinflammatory mechanisms caused by alcohol abuse.

• Functional genomics of lung cancer.
• Study of the mechanisms of resistance to targeted therapies against lung cancer using omics technologies.
• Identification of new biomarkers, biosensors and new therapeutic targets for the diagnosis, prognosis and treatment of cancer.
• Regulation of tumour metabolism by oncogenes and suppressor genes in lung cancer.
• Physiopathology of pulmonary fibrosis and epithelial-mesenchymal transition in lung pathology.
• Physiopathology of the retina.

• Neurohumoral mechanisms of circulation regulation.
• Reactivity of vessels used in coronary artery bypass grafting.
• Endothelial function under physiological and pathophysiological conditions.
• Role of T-type voltage-dependent calcium channels in hypertension.
• Epigenetics and atherosclerosis

• Study of the physiological and pathophysiological role of the aromatic hydrocarbon receptor pathway.
• Analysis of alterations in intestinal motility.
• Study of the effect of prebiotics and probiotics.
• Search for transcriptomic and/or metabolomic biomarkers in human samples and experimental models.
• Pathophysiology of constipation.

• Endothelial dysfunction associated with vascular senescence and metabolic syndrome.
• Endothelial factors in cirrhosis and chronic renal failure.
• Vascular physiology and physiopathology. Cell signalling mechanisms involved in cardiovascular diseases.

• Physiology and physiopathology of Alzheimer's disease.
• Physiology and physiopathology of physical exercise and sarcopenia.
• Multimodal strategies (nutrition and exercise) for healthy ageing.
• Exercise acts as an antioxidant in skeletal muscle.
• Physical exercise as a pharmacological alternative

•     Physiology and physiopathology of ageing and frailty.

• Stem cells, extracellular vesicles and ageing

• Molecular mechanisms involved in Alzheimer's disease
• Clinical neurophysiology in mild cognitive impairment and Alzheimer's disease.

• Nutrition and the immune system.
• Nutrition and longevity.
• Role of nutrients in healthy ageing. Pharmacological properties of foods and their constituent compounds, 
  role of polyphenols..

• Physiopathology of rare diseases
• Effect of oxidative stress on epigenetic regulation.
• Physiopathology of sepsis

• Physiopathology of acute pancreatitis.
• Physiopathology of liver diseases.
• Oxidative stress in gastroenterolog

• Perinatal Physiopatholo
• Physiological and pathological aspects of postnatal adaptation.
• Peculiarities of preterm birth.
• Physiological aspects of the foetal-neonatal transition.
• Study of biomarkers in the detection of neurological damage due to asphyxia.
• Microbiome in preterm infants with different types of feeding.
• Perinatal maternal stress and foetal repercussions.
• Effects of inhaled nitric oxide (NO) use in the preterm infant with persistent pulmonary hypertension.
• Experimental model of perinatal hypoxic preconditioning.
• Epigenetic aspects of oxygen supplementation in the fetal-neonatal transition.
• Impact of donated breast milk on the health and development of the preterm infant.

• Cardiac electrophysiology

• Hormonal regulation of endothelial function.
• Role of miRNAs in oestrogen regulation in cardiovascular ageing.
• Role of miRNAs in the development of acute myocardial infarction.
• Physiological changes associated with menopause.

• Intercellular signalling and physiological mechanisms involved.
• Alzheimer's disease and inflammation.
• Physiopathology of drug addiction.

• Neurogenesis and neuroregeneration

• Mitochondrial-endothelial dysfunction in cardiometabolic diseases.
• Physiology and Physiopathology of type 2 diabetes.
• New nanoparticles and antioxidant compounds for the treatment of diseases.
• Study of autophagy and endoplasmic reticulum stress in type 2 diabetes and obesity.
• Study of mitochondrial dynamics in type 2 diabetes and obesity.
• Type I diabetes: molecular mechanisms involved and cardiovascular risk.
• Antioxidants targeting mitochondria: application to cardiometabolic diseases

• Study of factors related to cell cycle control and mitosis in cancer.
• Analysis of alterations related to PARP inhibitors (iPARP) in high-grade epithelial tumours.
• Role of the AXL pathway as a biomarker of resistance to treatment in high-grade epithelial tumours.

• Oxidative, inflammatory, genetic and epigenetic biomarkers associated with rare respiratory diseases: alpha-1 antitrypsin deficiency; primary ciliary dyskinesia and cystic fibrosis.
• Development of new therapeutics based on epigenetic markers and gene therapy for the treatment of rare respiratory diseases: Alpha-1 antitrypsin deficiency; Primary ciliary dyskinesia and cystic fibrosis.

• Identificación de nuevas dianas terapéuticas en la enfermedad hepática crónica.
• Comunicación intercelular en la fibrosis hepática.
• Regulación del fenotipo de células estrelladas hepáticas: relevancia en la fisiopatología de la enfermedad hepática crónica.
• Reposicionamiento farmacológico en el tratamiento de la esteatosis hepática metabólica.
• Mecanismos celulares y moleculares implicados en la toxicidad hepática y metabólica de los fármacos antirretrovirales.

• Physical exercise as an intervention for healthy ageing.
• Physical exercise in chronic pain.
• Efficiency and safety of products and methods to increase and/or recover physical and mental performance.
• Prescription of physical exercise in apparently healthy populations and those with special needs.
• Physical conditioning and motor rehabilitation in the aquatic environment.
• Variations of ocular and cardiovascular parameters with physical exercise.

• Biomechanical and physiological analysis of the effect of sports material and equipment: insoles, compression 
  garments, implements... during sports practice.
• Biomechanical and physiological analysis of running.
• Biomechanical and physiological analysis of cycling.

• Biochemical-clinical and oxidative parameters in physiological and pathophysiological processes.

antonio.iradi@uv.es

• Neurophysiology of the sleep-wake cycle.
• Physiological and Physiopathology modifications during sleep
• Neurophysiological markers in sleep disorders.

• Physiopathology mechanisms in Myotonic Dystrophy and experimental therapies.
• Physiopathology mechanisms in LGMD1F and experimental therapies.
• Drug repositioning in spinal muscular atrophy.
• Discovery and development of therapeutic oligonucleotides.
• Mechanisms of cancer-induced muscular cachexia..

• Discovery of new therapeutic targets for the treatment of myotonic dystrophy type 1.
• Development of therapies aimed at muscular atrophy in myotonic dystrophy type 1.
• Design and development of oligonucleotides for the treatment of myotonic dystrophy type 1.

ariadna_bargiela@iislafe.es

• Study of biomarkers in the detection of neurological damage.
• Neurogenesis and neurodegeneration.
• Alzheimer's disease and inflammation.
• Development of a portable sensor for the determination of oxidative stress.

• Mechanisms by which neuroinflammation alters neurotransmission and induces cognitive and motor impairment in 
  hyperammonaemia and hepatic encephalopathy. Therapeutic implications.
• Alterations in glutamatergic and GABAergic neurotransmission in hyperammonaemia and hepatic encephalopathy. 
• Molecular mechanisms.
  Mechanisms by which hyperammonaemia and hepatic failure induce neuroinflammation..

• Characterisation of alterations in inflammation, neuroinflammation, brain function and structure associated with the onset of minimal hepatic encephalopathy: The Bcl-2 protein interactome in tumour models.