This edition presents the conclusions reached by Valencia University’s Econcult’s research unit, within the framework of the European 3C4 Incubators Project.Focusing on the interdependent relationships that appear between space as a context, culture, creativity and innovation, the work is presented as a theoretical reflection that links and relates different sections and approaches. The subjects that are treated are illustrated through a broad selection of international case studies. Finally, fleeing from the temptation to create an individualistic and narrow discourse, the contributions of external voices through individual articles complete the discourse, simultaneously highlighting other threads of continuity