Cultural and creative activities are an increasingly important factor for the development of territories. In times of globalization, competitiveness requires public policies that promote social and economic innovation. This phenomenon places culture and creativity at the center of strategies for regional and local development. Organizations and cultural agents become promoters of innovation. The rural world is no stranger to this dynamic, although it has its own specifics. Cultural entrepreneurship in relation to a cluster of artistic craftwork in the Chiana Valley (Tuscany, Italy) is used for illustrating and discussing these and other issues. For that, we turn to the main results generated by this project: promoting the craftwork sector and artistic mobility, international projection of the territory, awareness and social revitalization, and improvement of institutional coordination through the establishment of network actions.