The article provides a multidisciplinary review of the literature, both theoretical and empirical, to establish the state of the art regarding the relationship between cultural and creative industries and multidimensional well-being. Beyond a thorough analysis of the existing research, it also proposes an innovative theoretical framework that explains how this relationship is structured and through which channels impacts on well-being are generated. This approach seeks to contribute to both academic research and the design of public policies and cultural strategies. It is especially relevant for cultural managers, researchers, and policymakers aiming to better understand and enhance the connections between culture and quality of life.