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Description

The excipients used to transport active substances (both in therapeutics and cosmetics) are not inert. They can promote or delay absorption and as such, they shape the bioavailability in speed and magnitude of the molecules of interest. It is very important to validate this role in order to optimise the form of administration. Two objectives delimit the line: on the one hand, to describe the effect of the most commonly used vehicles and, on the other hand, to prepare nuts that improve the capacity to increase or decrease absorption depending on the systemic or topical target, respectively. The research group collaborates with other institutions (University of Saarland-Germany and University of Rio Grande do Sul-Brazil, mainly) in the preparation and characterisation of the vehicles. It is responsible for the release studies and the mathematical modelling of the kinetics, which allows the optimisation of the material. He also carries out stability studies.

Keywords

nanocarriers, liposomes, colloids, targeting, polymeric nanoparticles, solid lipid nanoparticles, bioavailability, controlled drug release, polymeric films, microneedles, drug safety

Frascati classification