The detection of analytes of biological importance such as amines Biógenas (AB) is a field of work that arouses great interest. These analytes are particularly important because of their usefulness as biomarkers in certain diseases or the need for their control in food. For its part, the NO and CO are also important neurotransmitters but with chemical characteristics completely different from those of the AB. This project is aimed at the preparation of chemical sensors for the detection of neurotransmitters. Most of the chemical sensors designed are based on the approximation of the complexing unit or reactive-signaling unit, but in the development of this research, new and underexploited transduction mechanisms will be explored. Thus, in addition to the use of compounds containing the structure of BODIPY which has interesting fluorescent properties, it will also be used the process of emission induced by aggregation (AIE) of different compounds as a mechanism of transduction in the recognition of the different neurotransmitters considered. The BODIPYs have shown that they are fluorophores very interesting because they can experience energy transfer processes that modify not only their absorption wavelengths but also emission. These characteristics are very useful for the design of probes for biological media.
Description
DGICYT MAT2015-64139-C4-4-R
Non-UV principal researchers
Ana Mª Costero Nieto
Start date
2016
January
End date
2018
December
Funding agencies:
Ministerio de Ciencia e innovación y universidades: