2010

Publicaciones 2010
Marta Varela-Rey, Nuria Martínez-López, David Fernández-Ramos, Nieves Embade, Diego F. Calvisi, Aswhin Woodhoo, Juan Rodríguez, Mario F Fraga, Josep Julve, Elisabeth Rodríguez-Millán, Itziar Frades, Luís Torres, Zigmund Luka, Conrad Wagner, Manel Esteller, Shelly C Lu, M Luz Martínez-Chantar, José M Mato. Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide 901587 - Hepatology (2010 )
Real JT, Martínez-Hervás S, Tormos MC, Domenech E, Pallardó FV, Sáez-Tormo G, Redon J, Carmena R, Chaves FJ, Ascaso JF, García-García AB. Increased oxidative stress levels and normal antioxidant enzyme activity in circulating mononuclear cells from patients of familial hypercholesterolemia. Metabolism. Feb;59(2):293-8 (2010)
Beltrán B, Nos P, Dasí F, Iborra M, Bastida G, Martínez M, O'Connor JE, Sáez G, Moret I, Ponce J. Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohn's disease. Inflamm Bowel Dis.;16: (1) 76-86 (2010)
Konstantinidou V, Covas MI, Muñoz-Aguayo D, Khymenets O, de la Torre R, Saez G, Del Carmen Tormos M, Toledo E, Marti A, Ruiz-Gutiérrez V, Ruiz Mendez MV, Fito M. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial.FASEB J. 24/(7): 2546-2557. (2010)
Medina-Remón A, Zamora-Ros R, Rotchés-Ribalta M, Andres-Lacueva C, Martínez-González MA, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Ruiz-Gutiérrez V, García de la Corte FJ, Fiol M, Pena MA, Saez GT, Ros E, Serra-Majem L, Pinto X, Warnberg J, Estruch R, Lamuela-Raventos RM; on behalf of the PREDIMED Study Investigators. Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutr Metab Cardiovasc Dis. Feb 16. (2010)
López-Fontal R, Zeini M, Través PG, Gómez-Ferrería M, Aranda A, Sáez GT, Cerdá C, Martín-Sanz P, Hortelano S, Boscá L. Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. PLoS One. Jan 14;5 (2010)
López-Uriarte P, Nogués R, Saez G, Bulló M, Romeu M, Masana L, Tormos C, Casas-Agustench P, Salas-Salvadó J. Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome. Clin Nutr.; 29(3): 373-380. (2010)
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress. FASEB J. Apr; 24(4): 1249-1260 (2010)
Martínez-González MA, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Aros F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MA, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, Portillo MD, Estruch R; for the PREDIMED Study Investigators. Cohort Profile: design and methods of the PREDIMED study. Int J Epidemiol. Dec 20 1-10. (2010)
Moya M, Gómez-Lechón MJ, Castell JV and Jover R. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chemico Biological Interactions. 184(3):376-87 (2010).
Benet M, Lahoz A, Guzman C, Castell JV and Jover R. CCAAT/enhancer-binding protein a (C/EBPa) and hepatocyte nuclear factor 4 a (HNF4a) synergistically cooperate with constitutive androstane receptor (CAR) to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: Application to the development of a metabolically competent human hepatic cell model Journal of Biological Chemistry. 285(37): 28457–28471. (2010)
Donato MT, Montero S, Castell JV, Gómez-Lechón MJ, Lahoz A. Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies. Anal Bioanal Chem. 396(6):2251-63 (2010).
Gómez-Lechón MJ, Castell JV, Donato MT. The use of hepatocytes to investigate drug toxicity. Methods Mol Biol. 640:389-415 (2010).
Gómez-Lechón MJ, Lahoz A, Gombau L, Castell JV, Donato MT. In vitro evaluation of potential hepatotoxicity induced by drugs. Curr Pharm Des. 16(17):1963-77 (2010).
Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A. Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo. Drug Metab Dispos. 38(9):1449-55 (2010).
Gómez-Lechón MJ, Tolosa L, Castell JV, Donato MT.Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project. Toxicol In Vitro. 24: 1879-8920 (2010)
Kassem, S., Heyman, M., Glaser, B., Bhandari, S., Motaghedi, R., Maclaren, N.K., Garcia-Gimeno, M.A., Sanz, P., Rahier, J., Rodríguez-Bada, P., Cobo-Vuilleumier, N. and Cuesta-Muñoz, A.L. Large islets, beta-cell proliferation and a glucokinase mutation. New England J. Med 362, 1348-1350 (2010).
Aguado, C., Sarkar, S., Korolchuk, V., Criado, O., Vernia, S., Boya, P., Sanz, P., Rodriguez de Córdoba, S., Knecht, E. and Rubinsztein, D.C. Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum. Mol. Genet. 19, 2867-2876 (2010).
Knecht, E., Aguado, C., Sarkar, S., Korolchuk, V., Criado, O., Vernia, S., Boya, P., Sanz, P., Rodriguez de Córdoba, S. and Rubinsztein, D.C. Impaired autophagy in Lafora disease. Autophagy, 6, 991-993 (2010).
Moreno, D., Towler, M.C., Hardie, D.G., Knecht, E. and Sanz, P. The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains AMP-activated protein kinase beta subunits. Mol. Biol. Cell 21, 2578-2588 (2010).
Garcia-Haro, L., Garcia-Gimeno, M.A., Neumann, D., Beullens, M., Bollen, M. and Sanz, P. The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphoporylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 b cells. FASEB Journal 24, 5080-5091 (2010).
García Martínez,J.M.; Valentín Gómez,E.; Peman,J.; Cantón,E.; Gómez García,M.; del Castillo Agudo ,L. .Identification of pathogenic yeast species by polymerase chain reaction amplification of the RPS0 gene intron fragment. Journal of Applied Microbiology.108, 1917-1927.(2010).
Felim, A., Herrera, G., Neudörffer, A., Blanco, M., O’Connor, J.E., Largeron, M Synthesis and in Vitro Cytotoxicity Profile of the R-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(-)-HHMA) : Comparison with Related Catecholamines. Chem. Res. Toxicol. 23: 211-219. . (2010)
Prado-Lopez, S., Conesa, A., Armiñán, A., Martínez-Losa, M., Escobedo-Lucea, C., Gandia, C., Tarazona, S., Melguizo, D., Blesa, D., Montaner, D., Sanz-González, S., Sepúlveda, P., Götz, S., O’Connor, J.E., Moreno, R., Dopazo, J., Burks, D.J., Stojkovic, M. Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium. Stem Cells. 28: 407-418(2010)
Cervelló, I., Gil-Sanchis, C., Mas, A., Delgado-Rosas, F., Martínez-Conejero, J.A., Galán, A., Martínez-Romero, A., Martínez, S., Navarro, I., Ferro, J., Horcajadas, J.A., Esteban, F.J., O’Connor, J.E., Pellicer, A., Simón, C. Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells. PlosOne 5 e10964: 1-15. (2010)
Yáñez A, Flores A, Murciano C, O'Connor, J.E., Gozalbo, D., Gil, M.L. Signalling through TLR2/MyD88 induces differentiation of murine bone marrow stem and progenitor cells to functional phagocytes in response to Candida albicans. Cell Microbiol. 12: 114-128. (2010)
Aguilar, C., Meseguer, M., Garcia-Herrero, S., Gil-Salom, M., O'Connor, J.E., and Garrido, N. Relevance of testicular sperm DNA oxidation for the outcome of ovum donation cycles. Fertil Steril 94: 979-988. (2010)
Almenar,L., Agüero, J., Martínez-Dolz, L., O'Connor, J.E., Sánchez-Lázaro, I., Navarro, J., Raso, R., Buendía, F. Clinical predictors of immunotolerance in heart transplantation. Transplant Proc. 42:3183-3185. (2010)
Burguete, M.I., Galindo, F., Izquierdo, M. A., O'Connor, J.E., Herrera, G., Luis, S. V., Vigara, L. Synthesis and evaluation of pseudopeptidic fluorescence pH probes for acidic cellular organelles: In vivo monitoring of bacterial phagocytosis by multiparametric flow cytometry. Eur. J. Org. Chem. 31: 5967–5979. (2010)
Codoñer-Franch, P; Murria-Estal, R; Tortajada-Girbés, M; del Castillo-Villaescusa, C; Valls-Bellés, V; Alonso-Iglesias, E. New factors of cardiometabolic risk in severely obese children: influence of pubertal status. Nutricion Hospitalaria, 25: 845-851 (2010).
Martinez-Hervas S.; Real J.T.; Ivorra C.; Priego A.; Chaves F.J.; Pallardó F.V.; Viña J.R.; Redon J.; CarmenaR.; Ascaso J.F. Increased plasma xantine oxidase activity is related to nuclear factor kappa beta activation and inflammatory markers in familial combined hyperlipemia. Nutrition Metabolism and Cardiovascular Diseases.20: 734 - 739. (2010)
Hawkins R.A.; Mokashi A.; Dejoseph M.R.; Viña J.R.; Fernstrom J.D. Glutamate permeabilily at the blood-brain in insulinopenic and insulin-resistant rats. Metabolism-Clinical and Experimental.59: 258 – 266 (2010)
Real J.T.; Martinez-Hervas S.; García-García A.B.; Civera M.; Pallardó F.V.; Ascaso J.F.; Viña J.R.; Chaves F.J.; Carmena R. Circulating mononuclear cells nuclear factor-kappa B activity, plasma xantine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia. European Journal of Clinical Investigation.40: 89 - 94.(2010).
Bosch A.; Eroles P.; Zaragozá R.; Viña J.R.; Lluch A. Triple-negative breast cancer: Molecular features,pathogenesis, treatment and current lines of research. Cancer Treatment Reviews. 36: 206 – 215 (2010)
Zaragozá R.; Bosch A.; Garcia C.; Sandoval J.; Serna E.; Torres L.; Garcia-Trevijano E.R.; Viña J.R. Nitric oxide triggers mammary gland involution after weaning: remodeling is delayed but not impaired in mice lacking inducible nitric oxide synthase.Biochemical Journal. 428:451 - 462. (2010).

Publicaciones año 2010