In patients with large vessel ischaemic stroke, the use of thrombectomy devices makes it possible to retrieve the occluding thrombus and make it available for analysis. The thrombus can be studied fresh, frozen or fixed for preservation and subsequent analysis. The aim is to subject thrombi to different types of analysis to obtain information on their characteristics, structure and composition, and to establish associations between the nature of the thrombus and clinical-radiological variables relating to the diagnosis, treatment and prognosis of stroke. It will also help to explain the behaviour of the thrombus during fibrinolysis and/or thrombectomy, enabling research and development of more effective thrombolytic treatments and thromectomy devices.

Cerebral ischaemia, mitophagy, inflammation, neuroprotection

• Medical and Health Sciences