... in emergency myelopoiesis during candidiasis and reveal the mechanisms involved in trained innate immunity during fungal infections.

The hypothesis we are currently working on is that HSPCs can directly detect microorganisms and contribute to protection against infection by different mechanisms, including their ability to differentiate into myeloid cells with an enhanced (trained) phenotype to face the pathogen and initiate the immune response.

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candida albicans, haematopoiesis, trained immunity, haematopoietic progenitors

• Microbiology
• Immunology