Use of secondary equilibria in reversed-phase liquid chromatography (RPLC)

Description

Commercially available RPLC columns do not allow the analysis of charged or highly polar compounds. A line is developed to improve chromatographic performance using secondary equilibria, with special emphasis on the addition of surfactants and ionic liquids to the mobile phase.

Keywords

HPLC, secondary equilibria, separation performance enhancement, micellar and sub-micellar liquid chromatography, ionic liquids

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