Analysis of histone post-translational modifications and the responsible machinery using Saccharomyces cerevisiae yeast as a model eukaryotic organism.
We are currently focused on studying histone modifications during the chronological ageing process of yeast. The cells are subjected to severe nutritional restriction. To prevent proliferation and growth, histone marks, globally and on particular gene sequences, as well as the composition and characteristics of histone modification enzyme complexes, are analysed throughout the time of senescence.
These studies are intended to provide new insights that are basic and common to eukaryotic cells. They are therefore the starting point for similar projects in mammalian and human cells.
To provide fundamental new knowledge on biology, particularly on the regulation of gene expression, in eukaryotic cells.
Histone modification during chronological yeast ageing
Analysis of histone marks during yeast cell ageing, globally and at the level of individual genes. Analysis of the enzyme complexes responsible for histone marks in old and young cells.
- SENDRA PEREZ, RAMON
- PDI-Catedratic/a d'Universitat
- Coordinador/a Curs
- ExpandirSENDRA PEREZ, RAMONPDI-Catedratic/a d'UniversitatCoordinador/a Curs
Burjassot/Paterna Campus
C/ Doctor Moliner, 50
46100 Burjassot (Valencia)
- SENDRA PEREZ, RAMON
- PDI-Catedratic/a d'Universitat
- Coordinador/a Curs
