The research group Laboratorio de Investigación en Células Endoteliales (L.In.C.E.) is made up of a multidisciplinary team of researchers with expertise in Vascular and Endocrine Physiology, Molecular Biology, Biochemistry, Cell Biology and Reproductive Biology.
The group's main line of research is the study of the vascular effects of oestrogens and other steroid hormones. To this end, a translational approach is used, involving endothelial cells in culture, experiments carried out in animal models and studies carried out in women who receive hormone replacement therapy after menopause. Recently, another line of research on endothelial dysfunction associated with ageing has been initiated. The group's research includes gene and protein expression studies, production of vasoactive substances and functional studies using molecular biology (PCR, RT-PCR, microarrays), biochemistry (western blot, immunofluorescence, ELISA, HPLC), cell biology (primary cultures of human endothelial cells, flow cytometry) and vascular physiology (vascular reactivity).
- Gender differences in the cardiovascular area.
- Vascular effects of sex hormones.
- Identification of new hormonally regulated signalling pathways in the endothelium.
- Interaction of sex hormones with proatherogenic factors.
- Determination of progenitor and circulating endothelial cells and their relationship with hormone treatment.
Analysis of endothelial production of vasoactive substances
Quantification of the main vasoactive compounds and study of the regulatory pathways involved.
Blasco Ibáñez Campus
Av. Blasco Ibáñez, 15
46010 València (Valencia)
