The group's work also focuses on the study of spatial regulatory mechanisms in cell cycle control, mechanisms that involve the control of the subcellular localisation of key proteins for cell cycle progression. In particular, the role of the karyopherin Msn5 in the control of transcription factors (Swi6, Swi4, Mbp1, Swi5, Whi5) as well as Start cyclins (Cln1, Cln2) has been studied. Furthermore, determinants of cyclin functional specificity and the identification of new mechanisms controlling cyclin synthesis and degradation (Cln2, Clb2) are investigated.

Cell cycle, cyclin, karyopherin, Swi6, Swi4, Swi5, Whi5, Mbp1, Cln1, Cln2, Clb2, Msn5, S. cerevisiae, yeast

• Cell Biology
• Molecular Biology
• Biochemistry