Resultats de la cerca71 resultats
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Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials
Estela Climent, Mustafa Biyikal, Kornelia Gawlitza, Tomas Dropa, Martin Urban, A. M. Costero; R. Martınez-Manez; Knut Rurack
(2017). ArticleSensors and Actuators B: Chem., vol. 246, pp. 1056-1065
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Assessing heat treatment of chicken breast cuts by impedance spectroscopy
Schmidt, F.C. ; Fuentes López, Ana; Masot Peris, Rafael; Alcañiz Fillol, Miguel; Laurindo, J.B. ; Barat Baviera, José Manuel
(2017). ArticleFood Science and Technology International, vol. 2, p. 110 - 118
DOI: 10.1177/1082013216659609 -
Primer design for SNP genotyping based on allele-specific amplificationApplication to organ transplantation pharmacogenomics
Tortajada-Genaro, Luis Antonio; Puchades, Rosa; Maquieira Catala, Angel
(2017). ArticleJournal of Pharmaceutical and Biomedical Analysis, vol. 136, p.14 - 21.
DOI: 10.1016/j.jpba.2016.12.030 -
Low-cost genotyping method based on allele-specific recombinase polymerase amplification and colorimetric microarray detection .
Yamanaka, Eric-Seiti; Tortajada-Genaro, Luis Antonio; Maquieira, A..
(2017). ArticleMicrochimica Acta, vol. 5, p. 1453 - 1462
DOI: 10.1007/s00604-017-2144-0 -
Enantioselective drug-plasma protein-binding studies by capillary electrophoresis
Escuder-Gilabert, L., Martín-Biosca, Y., Sagrado, S., Medina-Hernández, M.J.
(2017). LlibreChapter
In Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research
pp. 225-258
Pan Stanford Publishing Pte. Ltd.
Drug action in living organisms is the result of a large number of pharmacological processes. In this sense, the interactions between drugs and biomembranes, plasma proteins, enzymes, or receptors are decisive features of the final biological activity of drugs. Most of the pharmacological processes responsible of drug action present a high degree of stereoselectivity, resulting in a difference between the activities of the enantiomers of drugs. In fact, very often one of them is the most active, while the other may produce side effects and 226even toxicity in some cases [1]. Pharmacological differentiation of enantiomers may occur at pharmacodynamic and pharmacokinetic levels. The term pharmacokinetics involves all the processes that take place since a drug enters the human body and until the moment it is eliminated by different pathways. Pharmacokinetic processes are drug absorption, distribution, metabolism, and excretion, and all of them can be affected by enantioselectivity. The main prerequisite of a biological process for being enantioselective is stereospecific recognition of the enantiomers of drugs by a chiral biomolecule responsible for the process [2]. Examples of enantioselective processes include active transport, protein binding, or enzymatic reactions such as metabolism.
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NO2-controlled cargo delivery from gated silica mesoporous nanoparticles
L. Alberto Juárez; Ana M Costero; Margarita Parra; Pablo Gaviña; S. Gil; R. Martínez-Máñez
(2017). ArticleChem. Commun ., vol. 53, pp. 584-588
DOI: 10.1039/c6cc08885f -
Transdermal therapeutic systems for memantine delivery. Comparison of passive and iontophoretic transport.
Del Río-Sancho S, Serna-Jiménez CE, Sebastián-Morelló M, Calatayud-Pascual MA, Balaguer-Fernández C, Femenía-Font A, Kalia YN, Merino V, López-Castellano A.
(2017). ArticleInt. J. Pharm., vol. 517, pp. 104-111
DOI: 10.1016/j.ijpharm.2016.11.038 -
A voltammetric electronic tongue for the quantitative analysis of quality parameters in wastewater
Martínez-Bisbal, M.Carmen; Loeff, Edwin; Olivas, Estela; Carbó-Mestre, Noèlia; Garcia Castillo, F. Javier; López-Carrero, Javier; Tormos, Isabel; Tejadillos, F. José; Berlanga, J. Guillermo; Martínez-Máñez, Ramón; Alcañiz, Miguel; Soto Camino, Juan
(2017). ArticleElectroanalysis, vol. 4, p. 1147 - 1153
DOI: 10.1002/elan.201600717
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Simultaneous determination of four food allergens using compact disc immunoassaying technology.
Ali Badran, Ahmed; Morais, Sergi; Maquieira Catala, Angel
(2017). ArticleAnalytical and Bioanalytical Chemistry, vol. 49, p.2261 - 2268
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Population pharmacokinetics of lenalidomide in multiple myeloma patients
Guglieri-López B, Pérez-Pitarch A, Moes DJ, Porta-Oltra B, Climente-Martí M, Guchelaar HJ, Merino-Sanjuán M.
(2017). ArticleCancer Chemother. Pharmacol., vol. 79, pp. 189-200
DOI: 10.1007/s00280-016-3228-y