Next Thursday 15 December 2023 12:00 am on the Seminar Room - SS6 (Institutes building floor -1), Dr Murat Tugrul (Freie Universität in Berlin) will give a Seminar on "Evolution of nuclear receptor proteins and their DNA binding sites"
SEMINAR(i):
Evolution of nuclear receptor proteins and their DNA binding sites
WHO?: Dr. Murat Tugrul
Freie Universität in Berlin
LANGUAGE?: English
WHEN?: Thursday 15/12/2023 - 12:00 am.
WHERE?: Seminar Room - SS6 (Institutes building floor -1)
ABSTRACT:
Nuclear receptors (NRs) regulate gene expression in response to signaling molecules and environmental stimuli, influencing physiology and fitness. Their evolution is crucial for metazoan diversification and adaptation, yet the coevolution of NR protein sequences and regulatory features remains poorly understood. In this talk, I will present our results on key NR families in crustacean genomes, finding how slight motif changes trigger transcription factor binding site (TFBS) turnover, potentially rewiring gene regulatory networks. Finally, I will also discuss why the evolution of NR-related sequences appear to (dis-)agree with the currently accepted evolution of aquatic arthropods.
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