Search result71 results

• Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials

  Estela Climent, Mustafa Biyikal, Kornelia Gawlitza, Tomas Dropa, Martin Urban, A. M. Costero; R. Martınez-Manez; Knut Rurack

  (2017). Article

  Sensors and Actuators B: Chem., vol. 246, pp. 1056-1065

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• Assessing heat treatment of chicken breast cuts by impedance spectroscopy

  Schmidt, F.C. ; Fuentes López, Ana; Masot Peris, Rafael; Alcañiz Fillol, Miguel; Laurindo, J.B. ; Barat Baviera, José Manuel

  (2017). Article

   Food Science and Technology International, vol. 2, p. 110 - 118

  DOI: 10.1177/1082013216659609

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• Primer design for SNP genotyping based on allele-specific amplification—Application to organ transplantation pharmacogenomics

  Tortajada-Genaro, Luis Antonio; Puchades, Rosa; Maquieira Catala, Angel

  (2017). Article

  Journal of Pharmaceutical and Biomedical Analysis, vol.  136, p.14 - 21.

  DOI: 10.1016/j.jpba.2016.12.030

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• Low-cost genotyping method based on allele-specific recombinase polymerase amplification and colorimetric microarray detection .

  Yamanaka, Eric-Seiti; Tortajada-Genaro, Luis Antonio; Maquieira, A..

  (2017). Article

  Microchimica Acta, vol. 5, p. 1453 - 1462 

  DOI: 10.1007/s00604-017-2144-0

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• Enantioselective drug-plasma protein-binding studies by capillary electrophoresis

  Escuder-Gilabert, L., Martín-Biosca, Y., Sagrado, S., Medina-Hernández, M.J.

  (2017). Llibre

  Chapter

  In Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research

  pp. 225-258

  Pan Stanford Publishing Pte. Ltd.

  Drug action in living organisms is the result of a large number of pharmacological processes. In this sense, the interactions between drugs and biomembranes, plasma proteins, enzymes, or receptors are decisive features of the final biological activity of drugs. Most of the pharmacological processes responsible of drug action present a high degree of stereoselectivity, resulting in a difference between the activities of the enantiomers of drugs. In fact, very often one of them is the most active, while the other may produce side effects and 226even toxicity in some cases [1]. Pharmacological differentiation of enantiomers may occur at pharmacodynamic and pharmacokinetic levels. The term pharmacokinetics involves all the processes that take place since a drug enters the human body and until the moment it is eliminated by different pathways. Pharmacokinetic processes are drug absorption, distribution, metabolism, and excretion, and all of them can be affected by enantioselectivity. The main prerequisite of a biological process for being enantioselective is stereospecific recognition of the enantiomers of drugs by a chiral biomolecule responsible for the process [2]. Examples of enantioselective processes include active transport, protein binding, or enzymatic reactions such as metabolism.

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• NO2-controlled cargo delivery from gated silica mesoporous nanoparticles

  L. Alberto Juárez; Ana M Costero; Margarita Parra; Pablo Gaviña; S. Gil; R. Martínez-Máñez

  (2017). Article

  Chem. Commun ., vol.  53, pp.  584-588

  DOI: 10.1039/c6cc08885f

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• Transdermal therapeutic systems for memantine delivery. Comparison of passive and iontophoretic transport.

  Del Río-Sancho S, Serna-Jiménez CE, Sebastián-Morelló M, Calatayud-Pascual MA, Balaguer-Fernández C, Femenía-Font A, Kalia YN, Merino V, López-Castellano A.

  (2017). Article

  Int. J. Pharm., vol. 517, pp. 104-111

  DOI: 10.1016/j.ijpharm.2016.11.038

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• A voltammetric electronic tongue for the quantitative analysis of quality parameters in wastewater

  Martínez-Bisbal, M.Carmen; Loeff, Edwin; Olivas, Estela; Carbó-Mestre, Noèlia; Garcia Castillo, F. Javier; López-Carrero, Javier; Tormos, Isabel; Tejadillos, F. José; Berlanga, J. Guillermo; Martínez-Máñez, Ramón; Alcañiz, Miguel; Soto Camino, Juan

  (2017). Article

   Electroanalysis, vol. 4, p. 1147 - 1153 
   

  DOI: 10.1002/elan.201600717  

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• Simultaneous determination of four food allergens using compact disc immunoassaying technology.

  Ali Badran, Ahmed; Morais, Sergi; Maquieira Catala, Angel

  (2017). Article

  Analytical and Bioanalytical Chemistry, vol. 49, p.2261 - 2268

   

  DOI: 10.1007/s00216-016-0170-0

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• Population pharmacokinetics of lenalidomide in multiple myeloma patients

  Guglieri-López B, Pérez-Pitarch A, Moes DJ, Porta-Oltra B, Climente-Martí M, Guchelaar HJ, Merino-Sanjuán M.

  (2017). Article

  Cancer Chemother. Pharmacol., vol. 79, pp. 189-200

  DOI: 10.1007/s00280-016-3228-y

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