Príncipe Felipe Research Centre

Professor María Eugenia Armengod:

1. tRNA protein-modifiers.
2. Molecular basis of  breast cancer.

Professor Deborah Burks:

1. Analysis of the insuling/IRS-2 signaling pathway as molecular link between diabetic metabolism and neurodecay.
2. The role of IRS-2 in the regulation of the celular cycle of beta cells.
3. Obtaining insulin-producing cells from human embryo stem cells.

Professor Javier Cervera:

1. Study of the carbamoyl phosphate synthetase I deficiency (CPS I) and characterisation of the area of its activator N-acetyl-L-glutamate (AG).
2. Approaches to the structure and function, regulation and pathology of the enzyme delta1-pyrroline-5-carboxylic synthetase (P5CS): The 3D structure at an atomic level of the glutamate 5-kinase (G5K) of the Escherichia coli.
3. Production of monoclonal antibodies, identification of epitopes using expression bookshelves in the surface of bacteriophage viruses (“phage display”).

Professor Consuelo Guerri:

1. Glial cells, alcohol and development of the brain.
2. Neurotoxic and behavioural consequences of alcohol consumption during adolescence.
3. Alcohol and inflammation.
4. RHO GTPase in proliferation and inflammation. Implication of Rho GTPases in cell death and in the inflammation response induced by the ethanol in glial cells.

Professor José Hernández-Yago:

1. Regulation of the gene expression of the subunits if the mitochondrial Complex Translocase in human beings.
2. Identification of illnesses associated to malfunctions in the transportation of proteins to mitochondria.
3. Molecular bases of the Mohr-Tranebjærg syndrome.
4. Professor Erwin Knecht:
5. Regulation of the activity of the non-lysosome and yisosome systems of intracellular decay of proteins.
6. Implications in the pathologies of rare illnesses of alterations of the cellular proteolytic pathways by accumulation of non-degrading material or because of mitochondrial effects. 
7. Molecular mechanisms and functional importance of the degradative pathways different to macroautophages and proteasomes.

Professor José Anastasio Montero:

1. Study of the role of adult stem cell and endothelium precursors in the treatment of myocardial infarction.
2. Analysis of factors or molecules able to de inhibit  apoptosis of cardiomiocytes in vivo and cultured in low oxygen concentrations.
3. Influence of the ischemic niche over the viability and capacity of self-renovation of adult stem cells.

Professor José Luis Mullor:

1. Embryonic stem cell lines of the Japanese rice fish or medaka fish.
2. Role of de Nanog in embryonic development.
3. Regulation of the differentiation and proliferation of neural progenitors by the interaction of the SHH and WNT signaling pathways. 
4. Embryonic models of illnesses and toxicity.

Professor Rosa Farrás:

1. Genomic and proteomic research of B-CLL.
2. Regulation and function of the AP-1 transcription factor during the  A cyclin cell cycle, transcription and the ubiquitin-proteasome system.

Professor Vicente Felipo:

1. Molecular bases of the neurologic alterations in hyperammomenia and hepatic encephalopathy.
2. Effects on brain development of neurotoxic agents present in the environment and in the food chain.

Professor José Gallego:

1. Relations structure-activity in a viroid hammerhead ribozyme.
2. Blocking of the Rev-RRE interaction of the HIV-1 virus through organic ligans of low molecular weight.
3. Dynamics in the regime of milliseconds of complexes double-strand ADN and the antitumoral elinafide drug.

Professor Rosa Planells:

1. Cloning of new mechanoreceptors by means of the expression-cloning strategy.
2. Study of the regulation of the thermo-receptor TRPV1.

Professor Rafael Pulido:

1. Participation of the tumor suppressor phosphatase, PTEN, in the regulation of cell growth.
2. Regulation of the MAP kinase signaling pathways through phosphatase proteins of tirosines.
3. Study of the nuclear function of the tumoral suppressor PTEN in the astroglia and the mammary gland of genetically modified mice.

Professor Carlos Simón:

1. Derivation of stem cell lines of human embryonic origin of therapeutic grade.
2. Derivation of stem cell lines from blastocytes with specific monogenic alterations.
3. Derivation of human embryonic stem cell lines without destruction of the pre-embryo.
4. Use of fluorescent signalling systems.
5. Study of the growth and propagation supports of hESCs in an undifferentiated state.

Professor Miodrag Stojkovic:

1. Cellular reprogramming.
2. Differentiation of human embryonic stem cells (hESC) and adult stem cells to neural precursors.
3. Optimisation of culture procedures in conditions of free cultivation of animal products. 

Professor Marcel Vergés:

1. Identification and study of proteins associated to retromer.
2. Alterations of the endosome traffic regulated by retromer with implication in illnesses and development processes. 

Professor María Jesús Vicent:

1. Conductive polymers of defined tridimensional structure, water-solubles, biodegradables and biocompatible based in L-glutamic acid.
2. Polymeric nanomedicines for tissue regeneration. Focused to the treatment of ischemia and neurodegenerative illnesses.
3. Therapeutic polymers designed as combination therapy for the treatment of hormone-dependent tumors.