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Research projects funded by the Interministerial Commission on Science and Technology (CICYT)


SAF2013-43441-P

Modulación de la autofagia epitelial por los macrófagos: relevancia en la reparación mucosa en la enfermedad inflamatoria intestinal (2014, 3 years)
IP: Mª Dolores Barrachina Sancho and Francisca Sara Calatayud Romero
 

SAF2010-2023

Pathophysiological importance of theHIF-induced geneexpressionininflammatory bowel disease(2011,3 years).
IP: M. Dolores Barrachina
 
SAF2010-16030
Study of thecellular and molecular mechanismsthat mediatevasculartoxicityinducedby antiretroviral therapy(2011,3 years)
IP:  Ángeles Álvarez

 

SAF2007-64201 
Studyof theCellular and MolecularMechanismsThatMediatevasculartoxicityinducedbyantiretroviraltherapy(2011, 3 years)
IP:  M. Dolores Barrachina.

 

SAF2007-60021 
Efectos de los fármacos antirretrovirales sobre la interacción leucocito-endotelio. (2007, 3 years)
IP:  Ángeles Álvarez.

 

SAF2005-01366
Effectsof antiretroviral drugsonleukocyte-endotheliuminteraction.(2007,3 years)
IP:  Juan V. Esplugues.

 

SAF2004-06211
Pathophysiologicalrelevanceofinduciblenitric oxide synthaseinthe developmentofgastric lesionsinduced byNSAIDs(2004,3 years)
IP:  M. Dolores Barrachina.

 

SAF2004-002600
Nitric oxideas a regulatorof gene expressionviainducibletranscriptionfactorhypoxia (HIF): molecular mechanismsand physiologicaland pathological implications(2004,1 year)
IP:  Juan V. Esplugues.

 

SAF2001-0763
Actionsof nitric oxide oncell respirationand their involvement intheirpathogenic effects(2001,3 years)
IP:  Juan V. Esplugues. 

 

SAF 99-0114 
Neurohormonalregulationofgastric function:role of nitric oxide(1999,3 years)
IP:  M. Dolores Barrachina.

 

SAF98-0118 
Roleof nitric oxide inthegastrointestinalresponseto stress:involvementpathophysiological andpharmacologicalbases of action(1998,3 years)
IP:  Juan V. Esplugues.

 

IFD97-1029
Programme (ERDF)gastroprotectionbynitroglycerin patch.(1997,3 years)
IP:  Juan V. Esplugues 

 

DGICYT PM95-0145
Increased gastric mucosal defense induced by endotoxin and other stressors: Characterization of the role of nitric oxide. (1995, 3 years)
IP:  Juan V. Esplugues

 

SAF95-0472
Pharmacologicalanalysisofthegastrointestinalactionsnitrovasodilators.(1995,3 years)
IP:  Juan V. Esplugues. 

 

 

Research projectsfunded by theHealth Research Fund


PI14/00312
Papel de los fármacos anti-VIH en la aparición y/o progresión de la enfermedad de higado graso no alcohólico. (2015, 3 years)
IP: Juan V. Esplugues Mota y Nadezda Apostolova
 
PI13/01025
Disfunción endotelial-mitocondrial, estrés de retículo y autofagia en la diabetes tipo 2: Implicaciones fisiopatológicas, clínicas y terapeúticas (2014, 3 years).
IP: Victor Manuel Víctor González
 
PI13/00073
Efecto de la pérdida de peso sobre marcadores de estrés de retículo endoplasmático en la obesidad mórbida: Implicaciones fisiopatológicas y nuevas dianas terapéuticas (2014, 3 years).
IP: Milagros Rocha Barajas
 

 

PI11/00327
Characterization of novelcellular mechanisms ofantiretroviralhepatotoxicity.
IP: Juan V. Esplugues Mota

 

CB06/04/0071

Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas - CIBERehd (2006-present)
IP:  Juan V. Esplugues.

 

FIS PI10/01195.
Biomedical Research CentreNetwork inthe subject areaofLiver and DigestiveDiseases-CIBERehd(2006-present).
IP:  Víctor M. Víctor.

 

FIS PI081325
Toxicidad mitocondrial por fármacos antirretrovirales: Caracterización de un nuevo mecanismo agudo de acción (2008, 3 years)
IP:  Juan V. Esplugues

 

HelpIII(2009-1010)within theProgramofSupport forYoung ResearchersSupportCIBERehdyoung memberof theCIBERpartnerforhiring aresearch technician(2008).
IP:  Ángeles Álvarez.

 

FIS PI07/00171.
Oxidative stress andendothelial dysfunction: role ofnitricoxide(2008,2 years).
IP:  Victor M Victor.

 

ISupport(2007-2008)ayoung memberof theCIBERpartner.Helpayoung memberof theCIBERpartnerforhiring aresearch technician(2007).
IP:  M. Dolores Barrachina

 

C03/02 
HelpsDevelopmentCooperative ResearchThematic Networks.RNIHG.National Networkfor Research inHepatology andGastroenterology(2003,3 years)
IP:  Adolfo Benages M. Dolores Barrachina, Sara Calatayud.

 

CP03/0024 
Role of nitric oxidein cellular respirationinnormoxiaand hypoxia:physiological andpathophysiologicalimplications(2004,3 years).
IP:  Víctor M. Víctor.

 

FISPI02/0461 
Effectsof leptin onleukocyte-endotheliuminteractions(2002,3 years).
IP:  Sara Calatayud.

 

FIS 01/1187
Mechanismsofnitric oxide signalingin thegastrointestinalfunctionalism: Involvementof the nervous andimmunecomponents(2001,3 years).
IP:  Mª Dolores Barrachina. 

 

FIS 88-1947 
Influenceof blood pressurein the genesis ofgastric damageinducedPafacetherand thromboxane A2Duration: 1 year

 

FIS 87-1375 
Study ofgastricactionblockersofcalcium channels.Duration: 1 year

 

 

Research projects fundedby the Generalitat Valenciana


 

PROMETEOII/2014/035
Farmacología del tracto digestivo y la inflamación. Programa de ayudas para el desarrollo de actuaciones de I+D por grupos de investigación de excelencia Fase II (2014, 4 años)
IP: Juan V. Esplugues Mota

 

ACOMP/2013/236
Ayuda complementaria para el proyecto "Caracterización de nuevos mecanismos celulares de heptoxicidad por antirretrovirales" (2013, 1 año)
IP: Juan V. Esplugues Mota

 
PROMETEO/2010/60
PrometheusProgramforexcellent researchgroups(2010,5 years)
IP:  Juan V. Esplugues.

 

ACOMP/2010/169 
Additional aidfor R& Dbythe ValencianRegional Ministryon Education(2010, 1year)
IP:  Víctor M. Víctor

 

ACOMP/2010/207 
Additional aidtoprojectantiretroviralmitochondrialtoxicity:characterization of a novelacutemechanismof action.(2010, 1year)
IP:  Juan V. Esplugues. 

 

ACOMP/2009/194 
Additional aidtoprojectantiretroviralmitochondrialtoxicity:characterization of a novelacutemechanismof action.(2009, 1year)
IP:  Juan V. Esplugues. 

 

AP-030/09 
Study ofcardiovascularadverse effectsinducedby antiretroviral therapy(2009, 1year)
IP:  Ángeles Álvarez. 

 

ACOMP/2009/009 
Additional aidfor R& Dbythe ValencianRegional Ministryon Education(2009, 1year)
IP:  Víctor M. Víctor.

 

GVPRE/2008/216 
Effectof statins onthetranscriptionfactorHIF-1andendothelininhuman endothelialcellssubjected tohypoxia(2008,1 year)IP:  M. Ángeles Martínez.

 

GV/2007/074 
Systematic studyof the effectof antiretroviral drugsonleukocyte-endotheliuminteractions(2007, 1year)
IP:  Ángeles Álvarez.

 

GV2006-341 
Nitroglycerinand nitric oxide:mechanismsof action onmitochondriaand oxidative stress(2006, 1year)
IP:  Víctor M. Víctor.

 

ACOMP/2007/079 
Ayuda complementaria al proyecto al proyecto Protección mucosa gastrointestinal: una aproximación integradora desde el óxido nítrico mitocondria y HIF (2007, 1 año)
IP:  Juan V. Esplugues. 

 

ACOMP/2006-246
Additional aidto the projectthe projectProtectiongastrointestinalmucosa:an integrative approachfrommitochondrialnitric oxideandHIF(2007, 1year)
IP:  Juan V. Esplugues. 

 

GVAE06-137 
Vasculartoxicityof drugs usedin the therapyof AIDS(2006, 1year)
IP:  Juan V. Esplugues.

 

GRUPOS 05/043 
ResearchSupportgroups(2005, 1year)
IP:  Juan V. Esplugues.

 

GV2004-A-147 
Effectof nitric oxide oncell respirationandphysiologicaland pathophysiologicalimplications.(2004, 1year)
IP:  Víctor M. Víctor

 

ACOMP07-297 
Additional aidtoprojectpathophysiological importance of theinduciblenitric oxidesynthaseingastric lesionsinduced byNSAIDs(2007, 1year)  
IP:  M. Dolores Barrachina.

 

ACOMP06/237 
Additional aidtoprojectpathophysiological importance of theinduciblenitric oxidesynthaseingastric lesionsinduced byNSAIDs(2006, 1year)
IP:  M. Dolores Barrachina.

 

GV04B-185 
Pathophysiologicalrelevanceofinduciblenitric oxide synthaseinthe developmentofgastric lesionsinduced byNSAIDs(2004,2 years)
IP:  M. Dolores Barrachina.

 

GV04-B-184 
Actionsof nitric oxide oncell respirationand their involvement intheirpathogenic effects(2004,2 years). .
IP:  Juan V. Esplugues

 

S03/226 
ProjectExcellenceValencian Agencyfor Scienceand Technology(2003,2 years)
IP:  Juan V. Esplugues.

 

GRUPO03-226 
HelpGroupsI+D+I (2003, 1year)
IP:  Juan V. Esplugues.

 

GR01-212 
Supportresearch groupsOCYTGV2001 
IP:  Sara Calatayud.

 

 

PROJECTSinternational research


 

  • Contrato Marie Curie de la Comisión Europea. Endothelin-3/Endothelin receptor B signaling in the regulation of neural crest item cells migration: therapeutic potential for Hirschsprung’s disease. 2007-2009

           

  • Development cooperationproject(November 1997)Spanish Agency forInternationalCooperation.Decreasedmorbidity andmaternal and infant mortalityinurbanareaofthe city ofQuito.Duration 15months.

 

  • Development cooperationproject(November 1996)Spanish Agency forInternationalCooperation.Effect ofL-argininesupplementationon mortality inurbanchildrenofGuayaquil(Ecuador)Duration 15months.

 

  • JointResearch Project(Programfor Scientific Cooperationwith Latin Americafrom 1994 to 1996)Vascular reactivityinnormalpregnant womenwithpregnancy-inducedhypertension.

 

 

Support for the purchase,renovation or upgrading ofscientific-technological equipmentfor research infrastructure.


o IF08/3675. Health Research Fund(2008)

 

o INF05-GV-088. Generalitat Valenciana. (2005)

 

o INF03-100. Generalitat Valenciana / Valencian Agencyfor Scienceand Technology (2003)

 

o INF01-058. Department of Culture, Education and Science(2001)

 

o INF99-12-129. Department of Culture, Education and Science (1999)

 

o IN95-0297. NationalHealth andPharmacy (1995)