A

In this line of research we study the mechanisms that regulate the inflammatory response associated with different pathophysiological and pharmacological conditions in the gastrointestinal tract. It comprises two research projects:

• Study of the relevance of hypoxia in the inflammation associated with gastrointestinal damage induced by nonsteroidal antiinflammatory drugs (NSAIDs) and in inflammatory bowel disease. The main objective would be to analyse the role of gene expression induced by hypoxia-inducible factor (HIF) in epithelial cells and inflammatory cells in the mechanisms of mucosal damage and repair
• Regulation of the inflammatory process by gastrointestinal hormones whose secretion is increased in diseases of the digestive tract with an inflammatory component. The main objective would be to characterise the effect of gastrin on the role of the cells involved in the inflammatory/immunological response, and the relevance of these effects on processes such as Helicobacter pylori infection and colon cancer

   B

In this line of research we study the mechanisms responsible for the toxicity of antiretroviral therapy. We analyse functional responses using both in vitro cell models and in vivo animal models. Our main goal would be to analyse the mitochondrial implication and the cellular and molecular mechanisms in these actions seeking to define the basis for establishing which are the safest combinations of these drugs. We have focused on the following areas in particular:

•  Metabolic alterations
•  Hepatic toxicity
•  Vascular toxicity

http://www.pharmacologyvalencia.com/index.php/research