MAIN PUBLICATIONS (of the ten years)

1.García A, Torres-Ruiz S, Vila L, Villarroel-Vicente C, Bernabeu A, Eroles P, Cabedo N, Cortes D. Synthesis of 2-aminopropyl benzopyran derivatives as potential agents against triple negative breast cáncer. RSC Medicinal Chemistry 2023, in press, 106638 DOI: 10.1039/d3md00385j

2.Marques P, Villarroel-Vicente C, Collado A, García A, Vila L, Duplan I, Hennuyer N, Garibotto F, Enriz RD, Dacquet C, Staels B, Piqueras L, Cortes D, Sanz MJ, Cabedo N. Anti-inflammatory effects and improved metabolic derangements in ob/ob mice by a newly synthesized prenylated benzopyran with pan-PPAR activity. Pharmacological Research 2023, 187, 106638 DOI: 10.1016/j.phrs.2022.106638; PMID: 36586645

3.Vila L, Cabedo N, Villarroel-Vicente C, García A, Bernabeu A, Hennuyer N, Staels B, Franck X, Figadère B, Sanz MJ, Cortes D. Synthesis and biological studies of “polycerasoidol” and “trans-δ-tocotrienolic acid” derivatives as PPARα and/or PPARγ agonists.Bioorganic & Medicinal Chemistry 2022, 53, 116532.DOI: 10.1016/j.bmc.2021.116532; PMID: 34863066

4.Anza M, Endale M, Cardona L, Cortes D, Eswaramoorthy R, Cabedo N, Abarca B, Zueco J, Rico H, Domingo-Orti I, Palomino-Schatzlein M. Cytotoxicity, antimicrobial activity, molecular docking, drug likeness and DFT analysis of benzo[c]phenanthridine alkaloids from roots of Zanthoxylum chalybeum. Biointerface Research in Applied Chemistry 2021, 12, 1569-1586 DOI: 10.2147/AABC.S323657; PMID: 34447254

5.Parravicini O, Angelina E, Spinelli R, Garibotto F, Siano AS, Vila L, Cabedo N, Cortes D, Enriz RD. Design, synthesis, biological evaluation and molecular modelling of substituted pyrrolo[2,1-a]isoquinolinone derivatives: discovery of potent inhibitors of AChE and BChE New Journal of Chemistry 2021, 45, 8321-8334 DOI: 10.1039/d1nj00345c; PMID: 31268307

6.García, A, Vila L, Marín P, Bernabeu A, Villarroel-Vicente C, Hennuyer N, Staels B, Franck X, Figadère B, Cabedo N, Cortes D. Synthesis of 2-prenylated alkoxylated benzopyrans by Horner–Wadsworth–Emmons olefination with PPARα/γ agonist activity .ACS Medicinal Chemistry Letters 2021, 12-11, 1783-1786. DOI: 10.1021/acsmedchemlett.1c00400; PMID: 34795868

7.Villarroel-Vicente C, Gutiérrez-Palomo S; Ferri J, Cortes D, Cabedo N. Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview.European Journal of Medicinal Chemistry 2021, 221, 113535. DOI: 10.1016/j.ejmech.2021.113535; PMID: 33992930

8.Silva AG, Vila L, Marques P, Moreno L, Loza M, Sanz MJ, Cortes D, Castro C, Cabedo N.    1-(2′-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-demethyl-nuciferine as agonists in human D2 dopamine receptors. Journal of Natural Products 2020, 83, 127-133. DOI: 10.1021/acs.jnatprod.9b00921. PMID: 319333697

9.Neske A, Ruiz-Hidalgo J, Cabedo N, Cortes D. Acetogenins from Annonaceae family. Their potential biological applications. Phytochemistry 2020, 174, 112332 DOI:10.1016/j.phytochem.2020.112332. PMID: 32200068

10.Ruiz Hidalgo J, Gilabert M, Cabedo N, Cortes D, Neske A .Montanacin-L and montanacin-K two previously non-described acetogenins from Annona montana twigs and leaves.Phytochemistry Letters 2020, 38, 78-83. DOI: 10.1016/j.phytol.2020.04.016; PMID: 32200068

11.Bermejo A, Collado A, Barrachina I, Marques P, El Aouad N, Franck X, Garibotto F, Dacquet C, Caignard DH, Suvire FD, Enriz RD, Piqueras L, Figadère B, Sanz MJ, Cabedo N, Cortes D. Polycerasoidol, a natural prenylated benzopyran with dual PPARα/PPARγ agonist activity and antiinflammatory effect Journal of Natural Products 2019, 82, 1802-1812.DOI: 10.1021/acs.jnatprod.9b00003. PMID: 31268307

12.Bermejo A, Barrachina I, El Aouad N, Franck X, Chahboune N, Andreu I, Figadère B, Vila L, Hennuyer N, Staels B, Dacquet C, Caignard DH, Sanz MJ, Cortes D, Cabedo N. Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators. Bioorganic & Medicinal Chemistry 2019, 27, 115162. DOI: 10.1016/j.bmc.2019.115162. PMID: 31703893

13.Vettorazzi M, Vila L, Lima S, Acosta L, Yépes F, Palma A, Cobo J, Tengler J, Malik I, Alvarez S, Marqués P, Cabedo N, Sanz MJ, Jampilek J, Spiegel S, Enriz RD. Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity. Archiv der Pharmazie 2019, 352, 11800298 DOI: 10.1002/ardp.201800298. PMID: 30648282

14.Enriz RD, Tosso RD, Andújar SA, Cabedo N, Cortes D, Nogueras M, Cobo J, Vargas DF, Trilleras J. Indole-substituted 2,4-diamino-5,8-dihydropyrido[2,3-d]pyrimidines from one-pot process and evaluation of their ability to bind dopamine receptors. Tetrahedron 2018, 74, 7047-7057 DOI: 10.1016/j.tet.2018.10.038

15.Ismahene S, Ratiba S, Cortes Martínez DM, Cabedo N Phytochemical composition and evaluation of the antioxidant activity of the ethanolic extract of Calendula suffruticosa subsp. suffruticosa Vahl. Pharmacognosy Journal 2018, 10, 64-70. DOI: 10.5530/pj.2018.1.13

16.Parravicini O, Bogado ML, Rojas S, Angelina EL, Andujar SA, Gutierrez LJ, Cabedo N, Sanz MJ, López-Gresa MP, Cortes D, Enriz RD. Tetrahydroisoquinolines functionalized with carbamates as selective ligands of D2 dopamine receptor.Journal of Molecular Modeling 2017, 23, 1-14 DOI: 0.1007/s00894-017-3441-6; PMID: 28866777

17.Párraga J, Andújar SA, Rojas S, Gutierrez LJ, El Aouad N, Sanz MJ, Enriz RD, Cabedo N, Cortes D. Dopaminergic isoquinolines with hexahydrocyclopenta[ij]- isoquinolines as D2-like selective ligands European Journal of Medicinal Chemistry 2016, 122, 27–42 DOI: 10.1016/j.ejmech.2016.06.009; PMID: 27343851

18.Parraga J, Galán A, Sanz MJ, Cabedo N, Cortes D. Synthesis of hexahydrocyclopenta[ij]isoquinolines as a new class of dopaminergic agents European Journal of Medicinal Chemistry 2015, 90, 101-106 DOI: 10.1016/j.ejmech.2014.11.009; PMID: 5461315

19.Boulangé A, Parraga J, Galan A, Cabedo N, Leleu S, Sanz MJ, Cortes D, Franck X. Synthesis and antibacterial activities of cadiolides A, B and C and analogues. Bioorganic & Medicinal Chemistry 2015, 23, 3618-3628. DOI: 10.1016/j.bmc.2015.04.010; PMID: 25913865

20.Angelina E, Andújar S, Moreno L, Garibotto F, Párraga J, Peruchena N, Cabedo N, Villecco M, Cortes D, Enriz RD. 3-Chlorotyramine acting as ligand of the D2 dopamine receptor molecular modeling, synthesis and D2 receptor affinity. Molecular Informatics 2015, 34, 28 43.DOI: 10.1002/minf.201400093; PMID: 27490860

21.Párraga J, Moreno L, Díaz A, El Aouad N, Galan A, Sanz MJ, Caignard DH, Figadère B, Cabedo N, Cortes D. Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands. European Journal of Medicinal Chemistry 2014, 86, 700-709. DOI: 10.1016/j.ejmech.2014.09.038; PMID: 25232966

22.Cortes D, Moreno L, Párraga J, Galán A, Cabedo N.New medicines inspirated in Annonaceas. Revista Brasileira de Fruticultura 2014, 36, 22-31.

23.Moreno L, Berenguer I, Diaz A, Marin P, Parraga J, Caignard DH, Figadere B, Cabedo N, Cortes D. Synthesis of new melatoninergic hexahydroindenopyridines. Bioorganic & Medicinal Chemistry Letters 2014, 24, 3534-3536. DOI: 10.1016/j.bmcl.2014.05.053; PMID: 24930835

24.Parraga J, Cabedo N, Andujar S, Piqueras L, Moreno L, Galan A, Angelina E, Enriz RD, Ivorra MD, Sanz MJ, Cortes D. 2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands. European Journal of Medicinal Chemistry 2013, 68, 150-166. DOI: 10.1016/j.ejmech.2013.07.036; PMID: 23974015

25.Más N, Galiana I, Mondragon L, Aznar E, Climent E, Cabedo N, Sancenon F, Murguía JR, Martínez Mañez R, Marcos MD, Amoros P. Enhanced efficacy and broadening of antibacterial action of drugs via the use of capped mesoporous nanoparticles. Chemistry – A European Journal 2013, 19, 11167-11171. DOI: 10.1002/chem.201302170; PMID: 23839913

26.Escrig PV, Iglesias D, Corma A, Primo J, Primo Millo E, Cabedo N. Euphorbia characias as bioenergy crop: a study of variations in energy value components according to phenology and water status. Journal of Agricultural and Food Chemistry 2013, 61, 10096-10109.DOI: 10.1021/jf403015a; PMID: 24079468

27.Galan A, Moreno L, Parraga J, Serrano A, Sanz MJ, Cortes D, Cabedo N. Novel isoquinoline derivatives as antimicrobial agents. Bioorganic & Medicinal Chemistry 2013, 21, 3221-3230 DOI: 10.1016/j.bmc.2013.03.042; PMID: 23601815

28.Moreno L, Cabedo N*, Boulange A, Parraga J, Galan A, Leleu S, Sanz MJ, Cortes D, Franck X. Synthesis of pyrido[2,1-a]isoquinolin-4-ones and oxazino[2,3-a]isoquinolin-4-ones: new inhibitors of mitochondrial respiratory chain. European Journal of Medicinal Chemistry 2013, 69, 69-76. DOI: 10.1016/j.ejmech.2013.08.013; PMID: 24012711

29.Moreno L, Cabedo N, Ivorra MD, Sanz MJ, Lopez Castel A, Alvarez C, Cortes D. 3,4-Dihydroxy- and 3,4-methylenedioxy-phenanthrene type alkaloids with high selectivity for D2 dopamine receptor. Bioorganic & Medicinal Chemistry Letters 2013, 23, 4824-4827. DOI: 10.1016/j.bmcl.2013.06.078; PMID: 23886690

30.Hernandez Gil J, Ferrer S, Cabedo N, Lopez Gresa MP, Castiñeiras A, Lloret F. Two copper complexes from two novel naphthalene-sulfonyl-triazole ligands: Different nuclearity and different DNA binding and cleavage capabilities. Journal of Inorganic Biochemistry 2013, 125, 50-63. DOI: 10.1016/j.jinorgbio.2013.04.007; PMID: 23711426