In our group we design and synthesize ligands derived from the triazole ring and sulfonamide-type ligands, with which coordination compounds with different metal ions of biological interest [Cu(II), Zn(II), Fe(II,III),...] are prepared. The compounds are structurally and spectroscopically characterised. In a second stage, the interaction of the obtained complexes with DNA is studied, and their nuclease activity is tested with and without activating agents.

In a new and current approach, the activity of the metallo-nucleases synthesised in combination with QDs (quantum dots) is studied, with the aim of achieving an enhancement and/or activation of their nucleolytic properties. The effect of photoactivation (with harmless light) on the compounds and on the nuclease-QDs systems is also investigated. Finally, the most active systems are tested in vivo on tumour cell lines. In parallel, the magnetic properties of the polynuclear compounds obtained are studied. In the case of cyclic trinuclear compounds, examples of spin-frustrated systems, a more exhaustive antisymmetric exchange study is carried out.

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