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ARTERO ALLEPUZ, RUBEN DARIO

ARTERO ALLEPUZ, RUBEN DARIO

PDI-Catedratic/a d'Universitat

(9635) 43028

ruben.artero@uv.es

Biography
 

My academic formation is biochemistry. I did my thesis under Prof. Manuel Pérez Alonso's guidance, which led to the identification of the Drosophila gene muscleblind, the founder member of the Muscleblind-like (MBNL) family of alternative splicing regulators with critical roles in human genetic diseases such as myotonic dystrophy. After 6 years of postdoctoral training in Mary Baylies' laboratory at the Memorial Sloan-Kettering Cancer Center in New York, in 2001 I returned to Spain with a Ramón y Cajal research contract and started my independent research career at the University of Valencia where my overarching goal is to understand the mechanisms of pathogenesis and to discover therapeutic targets and innovative treatments of human genetic diseases, with a particular focus in myotonic dystrophy. To this end, we use human samples and animal and cell models to understand the molecular basis of disease, perform drug repurposing screenings, and evaluate the activity of oligonucleotide-based drugs. We actively seek a close relationship with clinical researchers and biotech companies.

BARRIO ESPARDUCER, ELADIO

BARRIO ESPARDUCER, ELADIO

PDI-Catedratic/a d'Universitat
Director/a de Servei General

Servei Central de Suport a la Investigació Experimental Edifici d'Investigació Dr Moliner, 50 46100 Burjassot - València. Departament de Biotecnologia, lab 309 Institut d'Agroquímica i Tecnologia dels Aliments CSIC Parc Científic de Paterna Carrer Catedràtic Escardino, 7 46980-PATERNA,...

(9635) 44180

eladio.barrio@uv.es

Biography
 

Born in Vinaròs (1961). Professor of Genetics at the School of Biological Sciences. He got a degree in Biological Sciences (Biochemistry) and a Ph.D. in Biology from the University of Valencia, with an extraordinary doctorate award.
His scientific career began as a predoctoral fellow of the Generalitat Valenciana at the University of Valencia. He did a two-year postdoctoral stay in the laboratory of Prof. Francisco J. Ayala from the University of California at Irvine (USA), and short stays as a visiting professor at the Technical University of Denmark (DTU), Kgs. Lyngby, Denmark, and at the Federal University of Minas Gerais, Belo Horizonte, Brazil. He was a researcher for 14 years at the “Cavanilles” Institute for Biodiversity and Evolutionary Biology, of the University of Valencia, and in the last eight years, he has been a researcher in the Systems Biology of yeasts of biotechnological interest Group at the Institute of Agrochemistry and Food Technology (IATA), CSIC, through an agreement between  CSIC and the University of Valencia.
During his research career, he has worked in different lines of research such as the molecular evolution of Drosophila, the evolution of RNA viruses, and the role of chaperonins in bacterial endosymbiosis. In recent years, his research work has focused on the study, through comparative genomics and the analysis of 'omic' data, of the molecular mechanisms involved in the generation of genetic innovations that explain the adaptation of yeasts of the genus Saccharomyces in fermentative environments, responsible for their properties of biotechnological interest.
He has participated in 26 competitive research projects, of which 9 as principal investigator. He is the author of more than one hundred articles in international journals indexed in the Science Citation Index. He has mentored 12 doctoral theses, supervised 3 postdoctoral researchers, and has been recognized for five six-year years periods of research.
His teaching activity currently focuses on subjects in the degrees in Biology and Biochemistry and Biomedical Sciences, in addition to the master's degree in R&D in Biotechnology and Biomedicine. He participated in the creation of the Master's Degree in Bioinformatics, being a member of its academic coordination committee for more than five years. He has six recognized five-year teaching periods. He was a member of the Senate of the University of Valencia and the faculty board of the School of Biological Sciences, during different periods.[Biography, English version]

BRACHO LAPIEDRA, MARIA ALMA

BRACHO LAPIEDRA, MARIA ALMA

PDI-Ajudant Doctor/A

961925969 (D)

alma.bracho@uv.es

CRAVA, MARIA CRISTINA

CRAVA, MARIA CRISTINA

PI-Invest Cont Ramon y Cajal
ESCRICHE SOLER, BALTASAR

ESCRICHE SOLER, BALTASAR

PDI-Catedratic/a d'Universitat
Director/a Titulacio Master Oficial
FERRE MANZANERO, JUAN

FERRE MANZANERO, JUAN

PDI-Catedratic/a d'Universitat
Director/a d' Institut Universitari

Departament de Genètica Facultat de Biologia, bloc B, 6ª planta 46100-Burjassot (València)

(9635) 44506

juan.ferre@uv.es

GARCIA MARTINEZ, JOSE

GARCIA MARTINEZ, JOSE

PDI-Titular d'Universitat
Director/a de Departament

Edificio B de Biología, 6ª planta Despacho 2.12.P6.038

96 3543402

jose.garcia-martinez@uv.es

GARCIA PEREZ, MIGUEL ANGEL

GARCIA PEREZ, MIGUEL ANGEL

PDI-Catedratic/a d'Universitat
GARCIA ROBLES, INMACULADA ROSA

GARCIA ROBLES, INMACULADA ROSA

PDI-Titular d'Universitat
Vicedega/Vicedegana / Vicedirector/a Ets
Biography
 

I have a degree in Chemistry specialising in Biochemistry from the Universitat de València (UV, 1994). I spent 5 months in the Goerlaeus laboratories of the University of Leiden (Netherlands). After graduating, I joined the Department of Genetics of the UV, where I did my doctoral thesis with an FPI Scholarship from the Generalitat Valenciana, obtaining my doctorate in 1999. During that period, I made a short stay (1996) at the Institute of Biotechnology of Cuernavaca (Mexico). I have done postdoctoral stays in different centers of recognized prestige, IATA (CSIC) (1999). Cavanilles Institute of Biodiversity and Evolutionary Biology (UV) (1999-2002) and EMBL (Grenoble, France, 2002-2004), with a Specialization Scholarship in International Organizations. Later I joined the Department of Genetics of the UV, with a postdoctoral fellowship Carmen and Severo Ochoa (2007-2009) and from 2009 to 2012 with a contract as a Senior Research Technician. In 2012 I competed and obtained a position as Associate Professor Dr and in 2017 as University Professor.

TEACHING ACTIVITY: Since 1996 I have taught in 21 different subjects, covering undergraduate or undergraduate students from second to master's degree. I have taught these classes in 2 degrees (Biology and Chemistry) and in 6 different degrees: Biochemistry and Biomedical Sciences (· BCB, 5), Biotechnology (BT, 5), Biology (Biol, 1), Double Degree Law-Criminology and Degree in Criminology (DC or C, 4) and in two master's degrees: Master in Molecular, Cellular and Genetic Biology (1) and Master in Bioinformatics (2).  I am currently coordinator of external internships of students in companies for the Degree in Biotechnology and I have the Quality Mention as a tutor of these practices. Since March 2018 I am Vice-Dean of Innovation and Quality of the Faculty of Biology. I have directed 13 final degree projects in the degrees of Biochemistry and Biomedical Sciences, Biotechnology and Criminology, 6 Master's Final Projects, and the Doctoral Thesis of Dr. López-Galiano: Identification of miRNAs with predictive value as biomarkers of biotic and abiotic stress in plants of agronomic interest. 26.03.2021 and I am co-directing another. I have recognized three five-year teaching periods

EDUCATIONAL INNOVATION ACTIVITIES: Since 2018 I have participated in 12 teaching innovation projects with 6 participations in congresses or educational days

RESEARCH CAREER: In my research career I have mainly addressed the field of pathogen-host interactions from a multitude of approaches, both in terms of the range of organisms (bacteria-insects, phages-bacteria, insects-plants, viruses-humans) and the type of approach, from purely molecular and basic research (phage structures, protein-protein interactions or biochemical characterization of the mode of action of toxins) to those of clinical or field application.  I have recognized three six-year periods of research. In 2014, I participated in the Potato Beetle genome annotation project, within the i5k initiative: genome sequencing of 5000 arthropods.

TRANSFER ACTIVITY: I am co-inventor of two patents: P0201030569- Increase in the expression of recombinant sequences in eukaryotes and ES27176855- Peptide and pharmaceutical compositions of the same for use as an antimicrobial and in the treatment of cancer. I have participated in the Innosalud (2020) and Innotransfer (2020,  2021) programs  .

PEER REVIEW AND EVALUATION ACTIVITIES Since 2009 I have participated as a reviewer in: Letters in  Applied Microbiology, Journal of Applied Microbiology, Cells, Plant Cell Reports, IJMS, BAOJ Biotechnology ... I participate as an external Evaluator for the National Agency for Evaluation and Foresight (ANEP) since 2015, for the Valencian Institute of Business Competitiveness (IVACE) since 2019 (21 business projects evaluated) and for the UV-Ministry of Universities, for the evaluation of the University Requalification System program (2021).

DISSEMINATION ACTIVITIES. Member of the Organizing Committee of Climathon-Burjassot 2019 (Climate Kick-UV), and Hackaton AgrotecUV (2021). Member of the organizing committee and the scientific congress  (Innocampus-Explora project) Innocovid19 (2020) and Innofuturo (2021 ).

GIL GARCIA, ROSARIO

GIL GARCIA, ROSARIO

PDI-Titular d'Universitat
Coordinador/a de Programa de Doctorat

Grup de Genètica Evolutiva, despatx 3.2.3 Institut de Biologia Integrativa de Sistemes (I2SysBio), Parc Científic de la Universitat de València, edifici 4 C/ Catedràtic Agustín Escardino, 9 46980 Paterna (València)

(9635) 43824

rosario.gil@uv.es

Biography
 

PhD in Pharmacy from the Universitat de València (1991), I did a postdoctoral stay of more than 3 years at the Eccles Institute of Human Genetics (University of Utah, USA). After 15 years dedicated to the study of the yeast Saccharomyces cerevisiae from almost any point of view (study of the cell wall, model system for the study of human tumor suppressor genes, analysis of stress and contamination in brewing yeast or global gene expression in wine yeasts), I joined the field of bacterial genomic evolution, in which I have been working since 2001 as a member of the Evolutionary Genetics group of the Universitat de València, where I am currently Associate Professor of Genetics.

I do my research at the Institute for Integrative Systems Biology (I2SysBio), a joint collaborative center Universitat de València - CSIC. My current work focuses on the study of the genome of endosymbiotic bacteria, which live inside specialized cells of  insect with restricted diets (such as aphids, weevils or mealybugs), to understand the relationship between these bacteria and their hosts, the bacterial genome reduction in these conditions, and its consequences for the inferred metabolic network. As a complement to these studies, I am also involved in studies on the definition of the minimal genome, essential for the maintenance of a living cell, and its implications in the field of Synthetic Biology. In this sense, in recent years we have started a new research line  in which we use the bacterial species Bartonella quintana as an endosymbiotic model for the design of a chassis that can be used in Synthetic Biology for therapeutic purposes.

Current research projects

Basic and applied approaches to unravel and modify model symbiotic systems. PGC2018-099344-B-I00 (co-financed by FEDER funds and Ministerio de Ciencia, Innovación y Universidades, Spain)

Evolution, experimental epidemiology and therapeutic engineering of the microbiota. PROMETEO/2018/133 (Generalitat Valenciana, Spain).

 

Recent and selected publications

Solana, J., E. Garrote-Sánchez and R. Gil (2021). DELEAT: gene essentiality prediction and deletion design for bacterial genome reduction. BMC Bioinformatics 22:444. doi:10.1186/s12859-021-04348-5 https://doi.org/10.1186/s12859-021-04348-5

Domínguez-Santos, R., A. E. Pérez-Cobas, P. Cuti, V. Pérez-Brocal, C. García-Ferris, A. Moya, A. Latorre, R. Gil (2021). Interkingdom gut microbiome and resistome of the cockroach Blattella germanica. mSystems 6:e01213-20. doi: 10.1128/mSystems.01213-20

Reyes-Prieto, M., R. Gil, M. Llabrés, P. Palmer-Rodríguez, A. Moya (2021). The metabolic building blocks of a minimal cell. Biology, 10:5. doi: 10.3390/biology10010005

Gil, R., A. Latorre (2019). Unity makes strength: a review on mutualistic symbiosis in representative insect clades. Life 9: 21; doi:10.3390/life9010021.

Gil, R., C. Vargas-Chavez, S. López-Madrigal, D. Santos-García, A. Latorre, A. Moya (2018). Tremblaya phenacola PPER: An evolutionary beta-gammaproteobacterium collage. ISME J. 12:124-135. doi: 10.1038/ismej.2017.144

López-Madrigal, S., R. Gil (2017). Et tu, Brute? Not even intracellular mutualistic symbionts escape horizontal gene transfer. Genes 8:247. doi: 10.3390/genes8100247

Lloréns-Rico, V., J. Cano, T. Kamminga, R. Gil, A. Latorre, W. H. Chen, P. Bork, J. I. Glass, L. Serrano, M. Lluch-Senar (2016). Bacterial antisense RNAs are mainly the product of transcriptional noise. Sci. Adv. 2:e1501363. doi: 10.1126/sciadv.1501363

Klein, A., L. Schrader, R. Gil, A. Manzano-Marín, L. Flórez, D. Wheeler, J. H. Werren, A. Latorre, J. Heinze, M. Kaltenpoth, A. Moya, J. Oettler (2016). A novel intracellular mutualistic bacterium in the invasive ant Cardiocondyla obscurior. ISME J. 10:376-388. doi: 10.1038/ismej.2015.119

Martínez-Díaz, V., A. Latorre, R. Gil (2016). Seasonal changes in the endosymbiotic consortia of aphids from the genus Cinara. Microbes Environ. 31:137-144. doi: 10.1264/jsme2.ME15118

Gil, R., J. Peretó (2015). Small genomes and the difficulty to define minimal translation and metabolic machineries. Front. Ecol. Evol. 3:123. doi: 10.3389/fevo.2015.00123

López-Madrigal, S., A. Latorre, A. Moya, R. Gil (2015). The link between independent acquisition of intracellular gamma-endosymbionts and concerted evolution in Tremblaya princeps. Front. Microbiol. 6:642. doi: 10.3389/fmicb.2015.00642

Gil, R. (2014). The minimal gene-set machinery. In Encyclopedia of Molecular Cell Biology and Molecular Medicine: Synthetic Biology, 2nd edition. Meyers RA (ed.). Wiley-VCH Verlag GmbH & Co. pp. 1-36. doi: 10.1002/3527600906.mcb.20130079

López-Madrigal, S., A. Beltrà, S. Resurrección, A. Soto, A. Latorre, A. Moya, R. Gil (2014). Molecular evidence for ongoing complementarity and horizontal gene transfer in endosymbiotic systems of mealybugs. Front. Microbiol. 5:449. doi: 10.3389/fmicb.2014.00449

Oakeson, K. F.*, R. Gil*, A. L. Clayton, D. M. Dunn, A. C. von Niederhausern, C. Hamil, A. Aoyagi, B. Duval, A. Baca, F.J. Silva, A. Vallier, D. G. Jackson, A. Latorre, R. B. Weiss, A. Heddi, A. Moya, C. Dale (2014). Genome degeneration and adaptation in a nascent stage of symbiosis. Genome Biol. Evol. 6:76-93. doi: 10.1093/gbe/evt210 *Equal contribution.

López-Madrigal, S., A. Latorre, M. Porcar, A. Moya, R. Gil (2013). Mealybugs nested endosymbiosis: going into the ‘matryoshka’system in Planococcus citri in depth. BMC Microbiol. 13:74. doi: 10.1186/1471-2180-13-74

Moya, A., R. Gil, A. Latorre., J. Peretó, M.P. Garcillán-Barcia, F. de la Cruz (2009). Towards minimal bacterial cells: evolution versus design. FEMS Microbiol. Rev. 33:225-235. doi: 10.1111/j.1574-6976.2008.00151.x

Moya, A., J. Peretó, R. Gil, A. Latorre (2008). Learning how to live together: genomic insights into prokaryote-animal symbioses. Nature Rev. Genet. 9:218-229. doi: 10.1038/nrg2319

Tamames, J.*, R. Gil*, A. Latorre, J. Peretó, F.J. Silva, A. Moya (2006). The frontier between cell and organelle: genome analysis of Candidatus Carsonella ruddii. Science 314:312-313. doi: 10.1186/1471-2148-7-181 *Equal contribution.

T. Gabaldón, J. Peretó, F. Montero, R. Gil, A. Latorre, A. Moya (2007). Structural analyses of a hypothetical minimal metabolism. Phil. Trans. R. Soc. B. Biol. Sci. 362:1751-1762. doi:  10.1098/rstb.2007.2067

Pérez-Brocal, V., R. Gil, S. Ramos, A. Lamelas, M. Postigo, J. M. Michelena, F. J. Silva, A. Moya, A. Latorre (2006). A small microbial genome: the end of a long symbiotic relationship? Science 314:312-313. doi: 10.1126/science.1130441

Gil, R., F. J. Silva, J. Peretó, A. Moya (2004). Determination of the core of the minimal bacterial gene set. Microbiol. Mol. Biol. Rev. 68: 518-537. doi: 10.1128/MMBR.68.3.518-537.2004

Gil, R., B. Sabater-Muñoz, A. Latorre, F. J. Silva, A. Moya (2002). Extreme genome reduction in Buchnera spp.: towards the minimal genome needed for symbiotic life. Proc. Natl. Acad. Sci. USA 99: 4454-4458. doi: 10.1073/pnas.062067299

GONZALEZ CABRERA, JOEL

GONZALEZ CABRERA, JOEL

PDI-Titular d'Universitat
Delegat/Delegada Rector/A

(9635) 43122

joel.gonzalez@uv.es

GONZALEZ CANDELAS, FERNANDO

GONZALEZ CANDELAS, FERNANDO

PDI-Catedratic/a d'Universitat

Despacho 1.5.D Instituto de Biología Integrativa de Sistemas, I2SysBio (CSIC-UV). Parc Científic. Paterna.

(9635) 43653

fernando.gonzalez@uv.es

Biography
 

Fernando González Candelas, PhD (University of Valencia, 1987) is Professor of Genetics at the University of Valencia since 2006 and head of the “Evolution and Health” Research Unit at the Institute for Integrative Systems Biology UV-CSIC (I2SysBio) at the same university. In addition, he has a joint appointment at the FISABIO-Public Health through the joint research unit “Infection and Public Health” with the University of Valencia and at the CIBERESP (Centre for Networked Research on Biomedicine – Public Health and Epidemiology).
    My main research interests are in population and evolutionary genetics, molecular and evolutionary epidemiology, molecular systematics and genomics, bioinformatics and conservation biology. I am currently working on the molecular evolutionary epidemiology of different pathogens, mainly RNA viruses, such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV), and bacteria, such as Legionella pneumophila, Treponema pallidum, Neisseria gonorrhoeae, Pseudomonas aeruginosa and Klebsiella pneumoniae. Our basic approach is the analysis of nucleotide sequence variability at different levels, from intrapatient to world-wide samples, and from particular genes to complete genomes, depending on the specific goals of the different projects. Previously I have studied the population and evolutionary biology of Mediterranean endemic Limonium (Plumbaginaceae) species, by using an array of genetic markers (RAPDs, AFLPs, microsatellites, isozymes) and including the analysis of quantitative traits. I have published more than 180 peer-reviewed scientific papers and written two books.

HERRERO SENDRA, SALVADOR

HERRERO SENDRA, SALVADOR

PDI-Titular d'Universitat
Director/a Titulacio Master Oficial
LOPEZ CASTEL, ARTURO

LOPEZ CASTEL, ARTURO

PDI-Ajudant Doctor/A
MARTINEZ TORRES, DAVID

MARTINEZ TORRES, DAVID

PDI-Catedratic/a d'Universitat
MOLTO RUIZ, MARIA DOLORES

MOLTO RUIZ, MARIA DOLORES

PDI-Catedratic/a d'Universitat

(9635) 43400

dolores.molto@uv.es

MOYA SIMARRO, ANDRES

MOYA SIMARRO, ANDRES

PDI-Catedratic/a d'Universitat

Integrative Systems Biology Institute (I2Sysbio); University of València and Spanish Research Council (CSIC); c/ Catedrático José Beltrán 2, 46980 Paterna, València, Spain. Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO); Avenida de Cataluña 21, 42...

(9635) 43480

andres.moya@uv.es

Biography
 

I studied simultaneously Biology and Philosophy at the Universitat de València (UV), obtaining a Ph.D. in Biology in 1983, and a Ph.D. in Philosophy in 1988. I was a Postdoctoral Fellow at the University of California, Davis (USA), in 1985-1986, and I have been invited Prof. in the University of California, Irvine (USA), in 1988 and 1994. After coming back from my post doctorate in the USA, in 1986, I created the Evolutionary Genetics Research Group at the Department of Genetics of the UV, where I am Prof. of Genetics since 1993, and have been its Director from 1995 to 1998. I was the promoter of the Cavanilles Institute of Biodiversity and Evolutionary Biology at the UV. I also promoted the creation of the Astrobiology Centre (CSIC-INTA), the Public Health Research Centre (CSISP), now integrated into the Valencian Region Foundation for the Promotion of Health (FISABIO) and the Integrative Systems Biology Centre (UV and Spanish Research Council, CSIC). Currently, I chair the Institutional Professorship FISABIO-UV.

I am author of about six hundred publications about Genetics, Evolution and Philosophy of Biology. My most significant contributions are in the fields of Symbiosis and Bacterial Genomics. I am involved in the study of the Human and Animal Microbiomes under an Evolutionary and Systems Biology perspective.

I am founder member of the European Society for Evolutionary Biology, the Spanish Society of Virology and the Spanish Society of Evolutionary Biology, from which I was president between 2009-2017.

I received the "Ciutat de Barcelona Award for Scientific Research" (1996), "Diario Médico Award" (2006), "Diploma of the President of the Valencian Government for excellence in Biomedical Research" (2010), "National Genetics Award" (2012), "Lilly Foundation Biomedical Research Award" (2013), "Mexico Award in Science and Technology" (2015), "Doctor Honoris Causa by Menendez Pelayo International University" (UIMP, Santander, 2016). I am a fellow of the American Association for the Advancement of Science since 1998.

OLTRA SOLER, JUAN SILVESTRE

OLTRA SOLER, JUAN SILVESTRE

PDI-Associat/Da Universitari/A
PARICIO ORTIZ, NURIA

PARICIO ORTIZ, NURIA

PDI-Catedratic/a d'Universitat

(9635) 43005

nuria.paricio@uv.es

PASCUAL CALAFORRA, LUIS FCO.

PASCUAL CALAFORRA, LUIS FCO.

PDI-Titular d'Universitat
Secretari/a de Departament

Departament de Genètica despatx nº 34 6è pis, edifici B Campus Burjassot-Paterna

(9635) 44504

luis.pascual@uv.es

PEREZ ALONSO, MANUEL

PEREZ ALONSO, MANUEL

PDI-Catedratic/a d'Universitat

Departamento de Genética Facultad de Biología (Bloque B, 6º piso) Campus de Burjasot

(9635) 43179

manuel.alonso@uv.es

RAUSELL SEGARRA, CAROLINA

RAUSELL SEGARRA, CAROLINA

PDI-Titular d'Universitat
REAL GARCIA, MARIA DOLORES

REAL GARCIA, MARIA DOLORES

PDI-Catedratic/a d'Universitat
SANJUAN VERDEGUER, RAFAEL

SANJUAN VERDEGUER, RAFAEL

PDI-Titular d'Universitat
Director/a Titulacio Master Oficial
SILVA MORENO, FRANCISCO J.

SILVA MORENO, FRANCISCO J.

PDI-Catedratic/a d'Universitat