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  • Iontophoresis for therapeutic drug delivery and non-invasive sampling applications

    Merino V, López-Castellano A, Delgado-Charro MB

    (2017). Llibre

    Percutaneous penetration enhancers: Physical Methods in Penetration Enhancement.

    pp. 77-101.

    Editors: Dragicevic N, Maibach HI.

    Ed.: Springer-Verlag.

    ISBN: 978-3-662-53271-3 (Print) 978-3-662-53273-7 (Online)
  • Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries.

    Vitonyte J, Manca ML, Caddeo C, Valenti D, Peris JE, Usach I, Nacher A, Matos M, Gutiérrez G, Orrù G, Fernàndez-Busquets X, Fadda AM, Manconi M.

    (2017). Article

    Eur. J. Pharm. Biopharm., vol. 114, pp. 278-287

    DOI: 10.1016/j.ejpb.2017.02.004
  • Capillary electrophoresis: Trends and developments in pharmaceutical research

    Kanchi, S., Sagrado, S., Sabela, M., Bisetty, K.

    (2017). Llibre

    Chapter

    In Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research

    pp. 1-396

    Pan Stanford Publishing Pte. Ltd.

    Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.

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  • Electrophoretically mediated microanalysis for evaluation of enantioselective drug metabolism

    Martín-Biosca, Y., Escuder-Gilabert, L., Sagrado, S., Medina-Hernández, M.J.

    (2017). Llibre

    Chapter

    In Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research

    pp. 277-304

    Pan Stanford Publishing Pte. Ltd.

    The study of xenobiotic metabolism is a key feature for the pharmaceutical and chemical industries since it is a determining factor both in the preclinical development of new drugs and in the toxicity evaluation of chemicals. Metabolic reactions usually make xenobiotics more polar and easier to be excreted and can be classified into two groups attending to the nature of the molecule modification. Phase I includes some reactions that generally lead 278to the introduction or uncovering of key functional groups (e.g., OH, COOH, NH2, and SH) increasing the molecule polarity, which may facilitate removal from the body. The main enzymatic system responsible for phase I reactions is the cytochrome P450 (CYP), despite other enzymes can also be involved. In phase II metabolism, there is a conjugation between the xenobiotic and some endogenous molecules or groups. It increases the molecule size, favoring its excretion and usually its inactivation. Not all compounds suffer phase I and II processes. Some compounds are directly eliminated after a phase I metabolic reaction or after a phase II conjugation

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  • Lateral flow immunoassay for on-site detection of Xanthomonas arboricola pv. Pruni in symptomatic field samples

    López-Soriano, P.; Noguera Murray, Patricia Silvestre; Gorris, María Teresa; Puchades, Rosa; Maquieira Catala, Angel ; Marco-Noales, E.; López, M.M.

    (2017). Article

    PLoS ONE, vol. 4, p. 1 - 13 

    DOI: 10.1371/journal.pone.0176201
  • Label-free piezoelectric biosensor for prognosis and diagnosis of Systemic Lupus Erythematosus.

    Mariane-Do Nascimento, Noelle; Juste-Dolz, Augusto; Grau-García, Elena; J.A. Roman-Ivorra; Puchades, Rosa; Maquieira Catala, Angel ... Giménez-Romero, David

    (2017). Article

     Biosensors and Bioelectronics, vol 9, p. 166 - 173.

    DOI: 10.1016/j.bios.2016.11.004
  • Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin

    Caddeo C, Manca ML, Matos M, Gutierrez G, Díez-Sales O, Peris JE, Usach I, Fernàndez-Busquets X, Fadda AM, Manconi M.

    (2017). Article

    Nanomedicine, vol. 3, pp. 1127-1136

    DOI: 10.1016/j.nano.2016.12.017
  • Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

    Lozoya-Agullo I, Araújo F, González-Álvarez I, Merino-Sanjuán M, González-Álvarez M, Bermejo M, Sarmento B.

    (2017). Article

    Mol. Pharm., vol. 14, pp. 1264-1270

    DOI: 10.1021/acs.molpharmaceut.6b01165
  • Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles

    Alba García-Fernández, Guillermo García-Laínez, M. Luisa Ferrándiz, Elena Aznar, Felix Sancenon, M. José Alcaraz, J. Ramón Murgía, M.D. Marcos, R. Martínez-Mañez, Ana M. Costero, Mar Orzáez

    (2017). Article

    J. of Controlled Release, vol.  248, pp. 60-70  

  • Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials

    Estela Climent, Mustafa Biyikal, Kornelia Gawlitza, Tomas Dropa, Martin Urban, A. M. Costero; R. Martınez-Manez; Knut Rurack

    (2017). Article

    Sensors and Actuators B: Chem., vol. 246, pp. 1056-1065