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  • Assessing heat treatment of chicken breast cuts by impedance spectroscopy

    Schmidt, F.C. ; Fuentes López, Ana; Masot Peris, Rafael; Alcañiz Fillol, Miguel; Laurindo, J.B. ; Barat Baviera, José Manuel

    (2017). Article

     Food Science and Technology International, vol. 2, p. 110 - 118

    DOI: 10.1177/1082013216659609
  • Primer design for SNP genotyping based on allele-specific amplification—Application to organ transplantation pharmacogenomics

    Tortajada-Genaro, Luis Antonio; Puchades, Rosa; Maquieira Catala, Angel

    (2017). Article

    Journal of Pharmaceutical and Biomedical Analysis, vol.  136, p.14 - 21.

    DOI: 10.1016/j.jpba.2016.12.030
  • Low-cost genotyping method based on allele-specific recombinase polymerase amplification and colorimetric microarray detection .

    Yamanaka, Eric-Seiti; Tortajada-Genaro, Luis Antonio; Maquieira, A..

    (2017). Article

    Microchimica Acta, vol. 5, p. 1453 - 1462 

    DOI: 10.1007/s00604-017-2144-0
  • Enantioselective drug-plasma protein-binding studies by capillary electrophoresis

    Escuder-Gilabert, L., Martín-Biosca, Y., Sagrado, S., Medina-Hernández, M.J.

    (2017). Llibre

    Chapter

    In Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research

    pp. 225-258

    Pan Stanford Publishing Pte. Ltd.

    Drug action in living organisms is the result of a large number of pharmacological processes. In this sense, the interactions between drugs and biomembranes, plasma proteins, enzymes, or receptors are decisive features of the final biological activity of drugs. Most of the pharmacological processes responsible of drug action present a high degree of stereoselectivity, resulting in a difference between the activities of the enantiomers of drugs. In fact, very often one of them is the most active, while the other may produce side effects and 226even toxicity in some cases [1]. Pharmacological differentiation of enantiomers may occur at pharmacodynamic and pharmacokinetic levels. The term pharmacokinetics involves all the processes that take place since a drug enters the human body and until the moment it is eliminated by different pathways. Pharmacokinetic processes are drug absorption, distribution, metabolism, and excretion, and all of them can be affected by enantioselectivity. The main prerequisite of a biological process for being enantioselective is stereospecific recognition of the enantiomers of drugs by a chiral biomolecule responsible for the process [2]. Examples of enantioselective processes include active transport, protein binding, or enzymatic reactions such as metabolism.

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  • NO2-controlled cargo delivery from gated silica mesoporous nanoparticles

    L. Alberto Juárez; Ana M Costero; Margarita Parra; Pablo Gaviña; S. Gil; R. Martínez-Máñez

    (2017). Article

    Chem. Commun ., vol.  53, pp.  584-588

    DOI: 10.1039/c6cc08885f
  • Transdermal therapeutic systems for memantine delivery. Comparison of passive and iontophoretic transport.

    Del Río-Sancho S, Serna-Jiménez CE, Sebastián-Morelló M, Calatayud-Pascual MA, Balaguer-Fernández C, Femenía-Font A, Kalia YN, Merino V, López-Castellano A.

    (2017). Article

    Int. J. Pharm., vol. 517, pp. 104-111

    DOI: 10.1016/j.ijpharm.2016.11.038
  • A voltammetric electronic tongue for the quantitative analysis of quality parameters in wastewater

    Martínez-Bisbal, M.Carmen; Loeff, Edwin; Olivas, Estela; Carbó-Mestre, Noèlia; Garcia Castillo, F. Javier; López-Carrero, Javier; Tormos, Isabel; Tejadillos, F. José; Berlanga, J. Guillermo; Martínez-Máñez, Ramón; Alcañiz, Miguel; Soto Camino, Juan

    (2017). Article

     Electroanalysis, vol. 4, p. 1147 - 1153 
     

    DOI: 10.1002/elan.201600717  
  • Simultaneous determination of four food allergens using compact disc immunoassaying technology.

    Ali Badran, Ahmed; Morais, Sergi; Maquieira Catala, Angel

    (2017). Article

    Analytical and Bioanalytical Chemistry, vol. 49, p.2261 - 2268

     

    DOI: 10.1007/s00216-016-0170-0
  • Population pharmacokinetics of lenalidomide in multiple myeloma patients

    Guglieri-López B, Pérez-Pitarch A, Moes DJ, Porta-Oltra B, Climente-Martí M, Guchelaar HJ, Merino-Sanjuán M.

    (2017). Article

    Cancer Chemother. Pharmacol., vol. 79, pp. 189-200

    DOI: 10.1007/s00280-016-3228-y
  • Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry

    Bañuls Polo, María-José; Jimenez-Meneses P.; Meyer, A.; Vasseur, J.J.; Morvan, F.; Escorihuela Fuentes, Jorge; Puchades, Rosa; Maquieira Catala, Angel

    (2017). Article

    Bioconjugate Chemistry, vol 2, p. 496 - 506. 

    DOI: 10.1021/acs.bioconjchem.6b00624