Molecular and genetic basis of neurocognitive alterations in patients with SMI, in order to develop biomarkers, diagnostic assessment tools and therapeutic interventions helping to improve the functional prognosis, the autonomy and the life quality of these people.
Comprehend the unexpected associations between apparently different diseases, like cancer and certain diseases of the central nervous system.
Prevention of fragility signs in populations at risk by assessing human functions (functional and neurocognitive assessment) and by incorporating nutritional medicine studies on Omega 3.
Bioavailability assessment: a) in vitro: gastrointestinal simulation and uptake and transport models with cell cultures and b) in vivo by determination of food components and metabolites in biological fluids and faeces, from clinical trials and animal experimentation.
We studied type 2 diabetes and mitochondrial dysfunction, having shown that it correlates with the development of silent ischaemic heart disease. We have also shown that high levels of myeloperoxidase correlate with the development of diabetic nephropathy in type 2 diabetes.
Basic translational research on biochemical and molecular mechanisms related to free radical formation and oxidative stress in metabolic, cardiovascular and tumour diseases. Molecular signalling pathways in DNA damage and repair.
