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From its inception, I²SysBio starts networking to build relationships and make agreements with any company interested in an integrative and systemic approach to biological problems. We propose a model of collaborative public-private alliance that allows companies to develop, within our laboratories, joint research projects of common interest in the context of the scientific programs of the institute. These alliances are based on the close and mutually beneficial interaction between I²SysBio members and partners from the industry.