Grups d'Investigació

GIUV2013-009

The research group Laboratorio de Investigación en Células Endoteliales (L.In.C.E.) is made up of a multidisciplinary team of researchers with expertise in Vascular and Endocrine Physiology, Molecular Biology, Biochemistry, Cell Biology and Reproductive Biology. The group's main line of research is the study of the vascular effects of oestrogens and other steroid hormones. To this end, a translational approach is used, involving endothelial cells in culture, experiments carried out in animal models and studies carried out in women who receive hormone replacement therapy after menopause. Recently, another line of research on endothelial dysfunction associated with ageing has been initiated. The group's research includes gene and protein expression studies, production of vasoactive substances and functional studies using molecular biology (PCR, RT-PCR, microarrays), biochemistry (western blot, immunofluorescence, ELISA, HPLC), cell biology (primary cultures of human endothelial cells, flow cytometry) and vascular physiology (vascular reactivity).

http://www.uv.es/lince/

• Diferencias de genero en el area cardiovascular
• Efectos vasculares de las hormonas sexuales
• Identificacion de nuevas rutas de señalizacion reguladas hormonalmente en el endotelio
• Interaccion de las hormonas sexuales con factores proaterogenicos
• Determinacion de celulas endoteliales progenitoras y circulantes y su relacion con el tratamiento hormonal

• Analysis of endothelial production of vasoactive compounds.Quantification of the main vasoactive compounds and study of the regulatory pathways involved.

• Physiology

• Endotelio, óxido nítrico, prostanoides, ciclooxigenasa, prostaciclina, tromboxano, estradiol, inmunodetección, celula
• PROSTANOIDS
• CYCLOOXYGENASE
• PROSTACYCLIN
• THROMBOXANE
• OESTRADIOL
• IMMUNODETECTION