GIUV2013-014
Analysis of histone post-translational modifications and the responsible machinery using Saccharomyces cerevisiae yeast as a model eukaryotic organism. We are currently focused on studying histone modifications during the chronological ageing process of yeast. The cells are subjected to severe nutritional restriction. To prevent proliferation and growth, histone marks, globally and on particular gene sequences, as well as the composition and characteristics of histone modification enzyme complexes, are analysed throughout the time of senescence. These studies are intended to provide new insights that are basic and common to eukaryotic cells. They are therefore the starting point for similar projects in mammalian and human cells.
- Proporcionar nou coneixement fonamental sobre la biologia, particularment sobre la regulacio de l'expressio genica, en cel·lules eucariotes
- Histone modifications in yeast chronological aging.Analysis of histone marks during yeast cell ageing, globally and at the level of individual genes. Analysis of the enzyme complexes responsible for histone marks in old and young cells.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| RAMON SENDRA PEREZ | Director | Universitat de València |
- -
- Biochemistry and Molecular Biology
- HISTONE
- CHROMATIN
- YEAST
- AGING
- EPIGENETICS
- HISTONE MODIFICATIONS
