Chemical Nucleases based on Coordination Compounds - NQCC

Reference of the Group:

GIUV2013-052

 
Description of research activity:

In our group we design and synthesize ligands derived from the triazole ring and sulfonamide-type ligands, with which coordination compounds with different metal ions of biological interest [Cu(II), Zn(II), Fe(II,III),...] are prepared. The compounds are structurally and spectroscopically characterised. In a second stage, the interaction of the obtained complexes with DNA is studied, and their nuclease activity is tested with and without activating agents. In a new and current approach, the activity of the metallo-nucleases synthesised in combination with QDs (quantum dots) is studied, with the aim of achieving an enhancement and/or activation of their nucleolytic properties. The effect of photoactivation (with harmless light) on the compounds and on the nuclease-QDs systems is also investigated. Finally, the most active systems are tested in vivo on tumour cell lines. In parallel, the magnetic properties of the polynuclear compounds obtained are studied. In the case of cyclic trinuclear compounds, examples of spin-frustrated systems, a more exhaustive antisymmetric exchange study is carried out.

 
Web:

No Determinada

 
Scientific-technical goals:
  • Sintetizar nuevos compuestos capaces de reconocer selectivamente al ADN mimetizando el enlace ADN-proteina
  • Obtener nuevas nucleasas oxidativas y/o hidroliticas; potenciar la actividad de las metalonucleasas mediante la combinacion con QDs (quantum dots)
  • Ensayar los compuestos mas activos sobre lineas celulares tumorales con el fin de obtener farmacos alternativos en quimioterapia
  • Evaluar la posible fotoactivacion de los sistemas QDs-metalonucleasas buscando una nueva generacion de farmacos para terapia fotodinamica
  • Obtener compuestos con propiedades magneticas relevantes por inusuales y/o por presentar el fenomeno de canje antisimetrico
 
Research lines:
  • Chemical Nucleases based on Coordination Compounds.Our research basically consists of the preparation and characterisation of new oxidative and/or hydrolytic metallo-nucleases, mainly based on metal ion coordination compounds of biological interest with triazole-type ligands and sulfonamide-type ligands.
 
Group members:
Name Nature of participation Entity Description
SACRAMENTO FERRER LLUSARDirectorUniversitat de València
Research team
M GLORIA ALZUET PIÑAMemberUniversitat de València
 
CNAE:
  • -
 
Associated structure:
  • Inorganic Chemistry
 
Keywords:
  • Nucleasa, interacción con el ADN, compuesto de coordinación, cobre, triazol, sulfonamida, magnetismo, canje antisimétrico, quantum dot