Signal and Modelling - SIGMO

Reference of the Group:

GIUV2013-063

 
Description of research activity:
Interactions between proteins play a significant role in the different functions of a cell. The function carried out by each protein is regulated by interaction with other proteins and different types of low molecular weight molecules. These interactions cause a change in the three-dimensional structure of a protein and, therefore, modulate its function. The group's research history has been varied, as it can be seen from the diversity of the members that we wish to be part of it. In addition to being included in the most recent publications of the most recent six-year period of each of the members applying, it must be said that bio-interactions are studied "in vitro", "in silico" and "in vivo". Due to their general complexity, these interactions require special latest technology instruments such as dual-polarisation Interferometry. This line of research focuses on the integration of experimental and computational information for the optimisation of intermolecular interactions. These interactions enable the development of new detection methodologies, as well as the design of new drugs aimed at target molecules involved in diseases and infectious processes. Furthermore, studies of...Interactions between proteins play a significant role in the different functions of a cell. The function carried out by each protein is regulated by interaction with other proteins and different types of low molecular weight molecules. These interactions cause a change in the three-dimensional structure of a protein and, therefore, modulate its function. The group's research history has been varied, as it can be seen from the diversity of the members that we wish to be part of it. In addition to being included in the most recent publications of the most recent six-year period of each of the members applying, it must be said that bio-interactions are studied "in vitro", "in silico" and "in vivo". Due to their general complexity, these interactions require special latest technology instruments such as dual-polarisation Interferometry. This line of research focuses on the integration of experimental and computational information for the optimisation of intermolecular interactions. These interactions enable the development of new detection methodologies, as well as the design of new drugs aimed at target molecules involved in diseases and infectious processes. Furthermore, studies of polymer-solvent binary and ternary interactions allow us to approach the interactions between polymers and biopolymers, as well as a whole world of research on new materials of a polymeric nature.
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Web:

http://www.uv.es/monzo/

 
Scientific-technical goals:
  • Afegir tractament de processament d'imatge i modelitzacio per tal d'ampliar els estudis de biointeraccio a situacions "in vitro, in silico i in vivo"
 
Research lines:
  • Structure study Biomacromolecules.Theoretical treatment and simulation through mechanics and molecular dynamics of biomacromolecule structures. Analysis and critical validation of coordinates. Calculation and prediction through the homology of structures with the application of quantum studies in specific cases. Molecular modelling and docking.
  • Spectroscopy.Where UV absorption and fluorescence and phosphorescence emission photophysics and spectroscopy devices are used. Dielectric permittivity measurements in organic liquids for the study of molecular structure, dipole moments and molar refraction.
  • Development of biosensors and immunosensors..This line of research focuses on the integration of experimental and computational information for the optimisation of intermolecular interactions. These interactions enable the development of new detection methodologies, as well as the design of new drugs aimed at target molecules.
  • Polymeric Materials.Study of the thermodynamics and transport phenomena of binary and ternary polymer systems.
 
Group members:
Name Nature of participation Entity Description
IOLANDA PORCAR I BOIXDirectorUniversitat de València
Research team
DAVID GIMENEZ ROMEROMemberUniversitat de València
 
CNAE:
  • -
  • -
 
Keywords:
  • Modelització;docking;RMN;PDB;Dinàmica;
  • Fluorescència;Fosforescència;Absorció;moment;dipolar;polaritzabilitat;refracció;
  • Sensat;Biosensors;Biointeracciones;
  • Viscositat;elasticitat;PCritic;