Translational Research Group on Pediatric Solid Tumors - ResPediaTu

Reference of the Group:

GIUV2016-286

 
Description of research activity:

Genetic analysis in solid tumours in children. At European level, we participate in the establishment of a uniform nomenclature, a standard operating procedure and quality validation studies, essential to obtain and maintain a high quality of the results of fluorescent in situ hybridisation, single nucleotide polymorphism and sequencing (FISH, SNPs and NGS) used for therapeutic stratification in neuroblastoma. Identification of new genetic factors and digital microscopic analysis with prognostic value in low prevalence tumours (rare tumours). Obtaining and characterising cell lines derived from fresh tumours of neuroblastic and skeletogenic tumours in children. Establishment and characterisation of in vivo models (2D and 3D) of neuroblastic tumours. Marker expression studies in paediatric solid tumours and colorectal carcinoma. Digital pathology studies of the tumour microenvironment.

 
Web:

http://www.incliva.es/investigacion/areas/oncologia/grupo-de-investigacion-translacional-de-tumores-solidos-pediatricos

 
Scientific-technical goals:
  • Estudios de Patologia Digital. Identificacion y validacion de biomarcadores diagnosticos, pronosticos y de seguimiento en muestras histologicas y sangre periferica de pacientes con neoplasias poco prevalentes y en los tumores artificiales relacionados diseñados.
 
Research lines:
  • Analysis of genetic prognostic factors in neuroblastoma (NB)..Detection of genomic changes. Identification and characterisation of unusual cases.
  • Development of pangenomic techniques of high performance in sarcomas..Use and improvement of tools for genetic diagnosis of tumours.
  • Digital microscopy analysis in histopathology.Detection, quantification and objective topology of biological parameters in histological samples.
  • Analysis of experimental tumours in animal models.Validation of clinically useful tests.
  • Analysis of histopathological prognostic factors in neuroblastoma (NB).Histological category determination and neuroblastic differentiation. Expression studies.
 
Group members:
Name Nature of participation Entity Description
ROSA NOGUERA SALVADirectorUniversitat de València
Research team
SAMUEL NAVARRO FOSMemberUniversitat de València
ANTONIO LLOMBART BOSCHCollaboratorUniversitat de València - Estudi GeneralUVEG honorary professor
ESTHER GAMERO SANDEMETRIOCollaboratorConsejo Superior de Investigaciones Científicastrainee research staff
ANA PILAR BERBEGALL BELTRANCollaboratorCentro de Investigación Biomédica en Red en Cancerresearcher
MAITE BLANQUER MACEIRASCollaboratorFUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA (FUNDACION INCLIVA)trainee research staff
NURIA BENAVENT GARCIACollaboratorUniversitat de València - Estudi GeneralUVEG PhD student
MARIA AMPARO LOPEZ CARRASCOCollaboratorFUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA (FUNDACION INCLIVA)researcher
EZEQUIEL MONFERRER GARZARANCollaboratorUniversitat de València
EZEQUIEL MONFERRER GARZARANCollaboratorUniversitat de València - Estudi GeneralUVEG PhD student
MERYEM EL OUARDI EL HAMIDYCollaboratorFUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA (FUNDACION INCLIVA)researcher
KARINA ALEXANDRA PARRA HAROCollaboratorCentro de Investigación Biomédica en Red en Cancerresearcher
SOFIA GRANADOS APARICICollaboratorCentro de Investigación Biomédica en Red en Cancerresearcher
 
CNAE:
  • -
 
Associated structure:
  • Pathology
 
Keywords:
  • Paediatric tumours, neuroblastoma, histopathology, tumour genetics
  • Tumores pediátricos, genética tumoral.
  • Paediatric tumours, neuroblastoma, tumour genetics.
  • Biomedical experimentation in animal models
  • Paediatric tumours, neuroblastoma, histopathology