GIUV2018-405
The Molecular Oncology group is strongly involved in translational research in cancer with special interest in the search for biomarkers related to angiogenesis, immunoregulation and tumour stem cells in cancer, characterised by its multidisciplinary nature. The team includes researchers with expertise in different areas such as: molecular and cell biologists, clinical oncologists, thoracic surgeons, pulmonologists, pathologists and immunologists. The group's research activity is linked to the General University Hospital of Valencia, a tertiary reference hospital in Valencia, and is closely associated with the activity of three important specialised departments: Medical Oncology (about 648,000 inhabitants), Thoracic Surgery (760,000 inhabitants) and Functional Breast Unit (648,000 inhabitants). They are also very active in recruiting patients for clinical trials. The main lines of translational research of the group are: 1) Molecular markers in lung, colorectal, melanoma and breast cancer, mainly focused on early diagnosis and the search for prognostic and predictive factors of response to treatment through different omics approaches (genomics, transcriptomics, metabolomics).
2)...The Molecular Oncology group is strongly involved in translational research in cancer with special interest in the search for biomarkers related to angiogenesis, immunoregulation and tumour stem cells in cancer, characterised by its multidisciplinary nature. The team includes researchers with expertise in different areas such as: molecular and cell biologists, clinical oncologists, thoracic surgeons, pulmonologists, pathologists and immunologists. The group's research activity is linked to the General University Hospital of Valencia, a tertiary reference hospital in Valencia, and is closely associated with the activity of three important specialised departments: Medical Oncology (about 648,000 inhabitants), Thoracic Surgery (760,000 inhabitants) and Functional Breast Unit (648,000 inhabitants). They are also very active in recruiting patients for clinical trials. The main lines of translational research of the group are: 1) Molecular markers in lung, colorectal, melanoma and breast cancer, mainly focused on early diagnosis and the search for prognostic and predictive factors of response to treatment through different omics approaches (genomics, transcriptomics, metabolomics).
2) Liquid biopsy: for the analysis of markers in minimally invasive samples.
3) Angiogenesis and immunoregulation. Study possible interrelationships between tumour neovascularisation, the presence of immunoregulatory cell populations (Tregs cells, myelosuppressive cells, dendritic cells) and tumour recurrence or progression.
4) Tumour stem cells (CSC): characterisation and isolation of CSCs from lung cancer patient samples. Development of in vitro and in vivo models for the design of new therapeutic strategies for CSC population control.
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- Validar biomarcadores minimamente invasivos que permitan la seleccion de individuos con mayor probabilidad de padecer cancer de pulmon
- Desarrollar modelos in vitro e in vivo a partir de CSC humanas (obtenidas de pacientes) destinado a probar nuevas estrategias terapeuticas que tenga
- Investigar sobre la inmunologia tumoral con el fin de encontrar nuevas dianas terapeuticas
- Integrar los conocimientos derivados del estudio del microambiente tumoral con el fin de desarrollar nuevos biomarcadores pronosticos y predictivos
- Fomentar la aplicabilidad de las investigaciones del grupo y las validaciones de sus hallazgos para poder trasladar sus resultados a la industria
- Molecular markers in oncology.Diagnostic, prognostic and/or predictive biomarkers: in lung cancer, head and neck cancer, colon cancer, breast cancer, melanoma, among others, through different omics approaches (genomics, transcriptomics, metabolomics).
- Liquid biopsy.Analysis of biomarkers in minimally invasive samples (saliva, blood, cerebrospinal fluid, pleural fluid, etc.), with the aim of improving diagnosis, personalising treatments and monitoring patients more closely (detection of resistance and relapses).
- Angiogenesis and immunoregulation.Study of interrelationships between tumour neovascularisation, the presence of immunoregulatory cell populations and recurrence or progression in the tumour microenvironment.
- Tumour Stem Cell (CSC).Characterisation and isolation of cancer stem cells (CSCs) from tumour samples. Development of in vitro and in vivo models for the design of new therapeutic strategies to control the CSC population.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| CARLOS CAMPS HERRERO | Director | Universitat de València | |
| Research team | |||
| JOSE VICENTE BAGAN SEBASTIAN | Collaborator | Universitat de València | |
| RICARDO GUIJARRO JORGE | Collaborator | Universitat de València | |
| CARMEN ESCOBEDO LUCEA | Collaborator | FUNDACIO INVESTIGACIO HOSPITAL GENERAL UNIVERSITARI VALENCIA | researcher |
| SUSANA MARIA GONZALEZ GRANERO | Collaborator | FUNDACIO INVESTIGACIO HOSPITAL GENERAL UNIVERSITARI VALENCIA | researcher |
| VEGA IRANZO GONZALEZ-CRUZ | Collaborator | Universitat de València | |
| INMACULADA CONCEPCIÓN MAESTU MAIQUES | Collaborator | Universitat de València | |
| INMACULADA CONCEPCIÓN MAESTU MAIQUES | Collaborator | Hospital Universitario Doctor Peset Aleixandre | head of section/service |
| ELENA DURENDEZ SAEZ | Collaborator | UNIVERSIDAD EUROPEA DE VALENCIA | researcher |
| JAVIER GARCIA PLANELLS | Collaborator | Genialitas Advisory, S.L. | research director |
| JUAN EDUARDO MEGIAS VERICAT | Collaborator | Conselleria de Sanitat Universal i Salut Pública | head of section/service |
| VICENTE GUILLEM PORTA | Collaborator | HOSPITAL VITHAS VALENCIA 9 DE OCTUBRE, S.A. | head of section/service |
| ANUAR RAMÓN GIMÉNEZ EL AMRANI | Collaborator | FUNDACIO INVESTIGACIO HOSPITAL GENERAL UNIVERSITARI VALENCIA | researcher |
| ANDRÉS SANZ GARCÍA | Collaborator | Universidad de Salamanca | pre-tenured lecturer |
| SARA MIRABET TORRES | Collaborator | FUNDACIO INVESTIGACIO HOSPITAL GENERAL UNIVERSITARI VALENCIA | researcher |
| ALFREDO SÁNCHEZ HERNÁNDEZ | Collaborator | Hospital Provincial de Castellón | head of section/service |
| SERGIO SANDIEGO CONTRERAS | Collaborator | FUNDACION INSTITUTO VALENCIANO DE ONCOLOGIA | researcher |
| JOSÉ GARCÍA SÁNCHEZ | Collaborator | Universitat de València - Estudi General | phisician |
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- Medicine
- Biomarcador, genómica,transcriptómica, metabolómica, oncología de precisión, predictivo, pronóstico, diagnóstico
- Biopsia líquida, sangre, biomarcadores
- Angiogenesis, inmunología tumoral, inmunoregulación, microambiente tumoral
- células madre, cultivos 3D, organoides, tumoresferas, esfeoirdes
