GIUV2021-518
The group's research focuses on metabolic alterations, primarily diabetes and insulin resistance states, as well as the complications associated with these diseases. Diabetes is a very prevalent disease, associated with multiple chronic complications, both micro and macrovascular (cardiovascular disease), which implies a high morbidity and mortality in the population, as well as a very high social health costs. The mechanisms that contribute to the development of these complications are not fully known. The group has a translational purpose. It is made up of clinical and regular researchers. It consists of staff attached to the University of Valencia, the Hospital Clínico Universitario de Valencia and the INCLIVA Biomedical Research Institute. Likewise, the research group has been part of the Biomedical Research Networking Centre in the area of Diabetes and Associated Metabolic Diseases (CIBERDEM) since its beginnings in 2008. Within CIBERDEM, the group's activities have focused on two of its strategic lines: epidemiology, genetics and epigenetics of diabetes mellitus. Chronic complications and comorbidities, and cellular and molecular mechanisms involved in the development and...The group's research focuses on metabolic alterations, primarily diabetes and insulin resistance states, as well as the complications associated with these diseases. Diabetes is a very prevalent disease, associated with multiple chronic complications, both micro and macrovascular (cardiovascular disease), which implies a high morbidity and mortality in the population, as well as a very high social health costs. The mechanisms that contribute to the development of these complications are not fully known. The group has a translational purpose. It is made up of clinical and regular researchers. It consists of staff attached to the University of Valencia, the Hospital Clínico Universitario de Valencia and the INCLIVA Biomedical Research Institute. Likewise, the research group has been part of the Biomedical Research Networking Centre in the area of Diabetes and Associated Metabolic Diseases (CIBERDEM) since its beginnings in 2008. Within CIBERDEM, the group's activities have focused on two of its strategic lines: epidemiology, genetics and epigenetics of diabetes mellitus. Chronic complications and comorbidities, and cellular and molecular mechanisms involved in the development and progression of type 2 diabetes and the identification of new therapeutic targets. The group's main lines of research are the following: diabetes, inflammation and arteriosclerosis; diabetes and fatty liver; pharmacogenetics and diabetes; diagnosis, prevention and treatment of diabetic foot ulcers; genetic factors involved in the regulation of body mass index and abdominal obesity; insulin resistance, inflammation and oxidative stress; postprandial lipemia and arteriosclerosis in insulin resistance states; and neurocognitive degeneration and diabetes.
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- Papel de los procesos inflamatorios asociados a la diabetes en la estabilidad de la placa y la esteatosis hepatica
- Papel de las variaciones geneticas en la respuesta al tratamiento farmacologico de la diabetes
- Estudio de ejes neuroendocrinos e inflamatorios implicados en la obesidad, resistencia a la insulina y diabetes
- Mecanismos involucrados en el desarrollo de pie diabetico y neurodegenracion en la diabetes
- Mecanismos implicados en las complicaciones cronicas de la diabetes
- Diabetes, inflammation and atherosclerosis.This line of research aims to study the molecular mechanisms that potentially connect these metabolic alterations.
- Diabetes and non alcoholic fatty liver disease.This line of research aims to study the molecular mechanisms that potentially connect these metabolic alterations.
- Pharmacogenetics and diabetes.This line of research aims to study the genetic mechanisms involved in the response to diabetes treatment.
- Genetic factors involved in the regulation of the body mass index and abdominal obesity.This line of research aims to study the genetic mechanisms involved in obesity.
- Insulin resistance, inflammation and oxidative stress.This line of research aims to study the molecular mechanisms that potentially connect these metabolic alterations.
- Postprandial lipemia and atherosclerosis in insulin resistance states.This line of research aims to study the molecular mechanisms that potentially connect these metabolic alterations with the development of arteriosclerosis.
- Diagnosis, prevention and treatment of diabetic foot.This line of research aims to study the mechanisms involved in the development of diabetic foot and how to improve the diagnostic and therapeutic processes of this entity
- Neurocognitive degeneration and diabetes.This line of research aims to study the molecular mechanisms that potentially connect these metabolic alterations with the development of neurocognitive alterations.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| SERGIO MARTINEZ HERVAS | Director | Universitat de València | |
| Research team | |||
| JOSE TOMAS REAL COLLADO | Member | Universitat de València | |
| JORDI FERRI CISCAR | Member | Universitat de València | |
| MARTA PEIRO SIGNES | Collaborator | Universitat de València | |
| MARTA PEIRO SIGNES | Collaborator | FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA (FUNDACION INCLIVA) | pharmacist |
| Esther Benito Casado | Collaborator | Centro de Investigación Biomédica en Red del Área de Diabetes y Enfermedades Metabólicas (Barcelona) | doctor |
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- Medicine
- Diabetes; inflamación; arteriosclerosis
- Diabetes; hígado graso; NAFLD
- Farmacogenética; diabetes; SNP
- Genética; SNP; obesidad; IMC; obesidad abdominal
- Resistencia a la insulina; inflamación; estrés oxidativo
- Lipemia postprandial; resistencia a la insulina; arteriosclerosis
- Pie diabético; diabetes
- Diabetes; degenración neurocognitiva
