GIUV2021-507
The Oral Precancer and Cancer Research Group focuses on the study of premalignant lesions and oral cancer in their various forms of presentation in the oral cavity and on the identification and validation of new biomarkers used for the early diagnosis of oral cancer. To this end, we carried out longitudinal studies in patients with pre-cancer and oral cancer, analysing the most relevant risk factors and integrating them with omics studies from tissue samples obtained by biopsies and salivary samples, such as the search for epigenomic, transcriptomic (RNAseq) and metagenomic alterations between the different types of potentially malignant oral lesions, and in turn establishing their distinction with oral squamous cell carcinomas. In summary, we aim to know the factors that can help us, both clinically and biomolecularly, in the early diagnosis of oral cancer. Recent articles published in journals indexed in the Science Citation Index: Bagan J, Martorell M, Cebrián JL, Rubert A, Bagán L, Mezquida C, Hervás D. Effect of clinical and histological features on time to malignancy in 224 cases of oral leukoplakia treated by surgery. Clin Oral Investig. 2022 Apr 26. Lorenzo-Pouso AI, Bravo...The Oral Precancer and Cancer Research Group focuses on the study of premalignant lesions and oral cancer in their various forms of presentation in the oral cavity and on the identification and validation of new biomarkers used for the early diagnosis of oral cancer. To this end, we carried out longitudinal studies in patients with pre-cancer and oral cancer, analysing the most relevant risk factors and integrating them with omics studies from tissue samples obtained by biopsies and salivary samples, such as the search for epigenomic, transcriptomic (RNAseq) and metagenomic alterations between the different types of potentially malignant oral lesions, and in turn establishing their distinction with oral squamous cell carcinomas. In summary, we aim to know the factors that can help us, both clinically and biomolecularly, in the early diagnosis of oral cancer. Recent articles published in journals indexed in the Science Citation Index: Bagan J, Martorell M, Cebrián JL, Rubert A, Bagán L, Mezquida C, Hervás D. Effect of clinical and histological features on time to malignancy in 224 cases of oral leukoplakia treated by surgery. Clin Oral Investig. 2022 Apr 26. Lorenzo-Pouso AI, Bravo SB, Carballo J, Chantada-Vazquez MDP, Bagan J, Bagan L, Chamorro-Petronacci CM, Conde-Amboage M, Lopez-Lopez R, Garcia-Garcia A, Perez-Sayáns M. Quantitative proteomics in medication-related osteonecrosis of the jaw: A proof-of-concept study. Oral Dis. 2022 Apr 4. Lorenzo-Pouso AI, Bagán J, Bagán L, Gándara-Vila P, Chamorro-Petronacci CM, Castelo-Baz P, Blanco-Carrión A, Blanco-Fernández MÁ, Álvarez-Calderón Ó, Carballo J, Pérez-Sayáns M. Medication-Related Osteonecrosis of the Jaw: A Critical Narrative Review. J Clin Med. 2021 Sep 24;10(19):4367. COVIDSurg Collaborative; GlobalSurg Collaborative. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563. COVIDSurg Collaborative; GlobalSurg Collaborative. Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia. 2021 Nov;76(11):1454-1464. Principe S, Zapater-Latorre E, Arribas L, Garcia-Miragall E, Bagan J. Salivary IL-8 as a putative predictive biomarker of radiotherapy response in head and neck cancer patients. Clin Oral Investig. 2022 Jan;26(1):437-448. Herreros-Pomares A, Llorens C, Soriano B, Zhang F, Gallach S, Bagan L, Murillo J, Jantus-Lewintre E, Bagan J. Oral microbiome in Proliferative Verrucous Leukoplakia exhibits loss of diversity and enrichment of pathogens. Oral Oncol. 2021 Sep;120:105404. Ramos-García P, González-Moles MÁ, Mello FW, Bagan JV, Warnakulasuriya S. Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta-analysis. Oral Dis. 2021 Nov;27(8):1896-1907. Seoane J, Warnakulasuriya S, Bagán JV, Aguirre-Urizar JM, López-Jornet P, Hernández-Vallejo G, González-Moles MÁ, Pereiro-Ferreiros M, Seoane-Romero J, Varela-Centelles P. Assembling a consensus on actinic cheilitis: A Delphi study. J Oral Pathol Med. 2021 Nov;50(10):962-970. Dikova V, Jantus-Lewintre E, Bagan J. Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma. J Clin Med. 2021 Apr 13;10(8):1658.
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- 1. Comprobar que hallazgos clinicos e histologicos de las leucoplasias orales influiran mas a la hora de la posible transformacion maligna.
- 2. Comprobar que tipos clinicos influyen mayormente en el desarrollo del cancer oral. Se miden por procedimientos matematicos informaticos.
- 3. Investigar patrones epigeneticos en el precancer y cancer oral.
- 4. Investigar patrones de RNAseq en el precancer y cancer oral.
- 5. Constatar si existen alteraciones en metagenomica de estas lesiones comparado con grupos controles sanos.
- Biomarkers in oral cancer and precancer.Our aim is to carry out clinical-pathological and biomolecular studies (methylation, RNAsea and metagenomics) with the main objective of obtaining a biomarker in saliva or in biopsy samples that is predictive of the malignant transformation of potentially malignant lesions and oral cancer.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| JOSE VICENTE BAGAN SEBASTIAN | Director | Universitat de València | |
| Research team | |||
| ENRIQUE ZAPATER LATORRE | Member | Universitat de València | |
| LETICIA BAGAN DEBON | Member | Universitat de València | |
| JOAN VILA FRANCES | Collaborator | Universitat de València | |
| JUAN SANDOVAL DEL AMOR | Collaborator | INSTITUTO DE INVESTIGACION SANITARIA LA FE (VALENCIA) | CEO |
- -
- Stomatology
- Precancer, leucoplasia, cancer oral
