GIUV2023-582
Currently, the group's main research activity is focused on the study of high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC).We essentially focused on the study of the generation of drug resistance through cell models, murine models and patient samples.
- Estudio de AXL-GAS6 como mecanismo de resistencia a inhibidores de PARP en COSAG y CMTN a traves del estres replicativo y la inmunomodulacion
- Analisis del papel de la via p53-Aurora kinasa como potenciales biomarcadores predictivos y dianas terapeuticas en COSAG y CMTN
- Analisis de AXL y la transicion epitelio mesenquima como mecanismo de resistencia a inhibidores de PARP en cancer de ovario de alto grado
- Estudio del papel de trabectedina en reversion a resistencias a platino e inihidores de PARP
- Study of the generation of drug resistance in high-grade serous ovarian cancer and triple negative breast.The group focuses on studying the generation of mechanisms of resistance to different drugs used in clinical practice for ovarian cancer, specifically high-grade serous ovarian cancer (HGSOC) and triple negative breast cancer (TNBC).
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| BEGOÑA PINEDA MERLO | Director | Universitat de València | |
| Research team | |||
| M ELENA OBRADOR PLA | Collaborator | Universitat de València | |
| JOSE ALEJANDRO PEREZ FIDALGO | Collaborator | Universitat de València | |
| JOSE ALEJANDRO PEREZ FIDALGO | Collaborator | Hospital Clínico Universitario de Valencia | doctor |
| Juan José Martinez Pretel | Collaborator | Universitat de València - Estudi General | UVEG PhD student |
- -
- cáncer; mama; ovario; resistencias; fármacos
