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Title: Directed evolution of oncolytic virus.

Research Group: Virus Experimental Evolution

We use directed evolution for creating modified viruses that selectively infect and destroy tumors (oncolytic viruses). Cancer cells typically show innate immunity defects, which makes them highly susceptible to viral infections. By adapting a virus to tumors in the laboratory, it is possible to enhance the ability of this particular virus to kill cancer cells and to stimulate an immune response against the tumor. This may open new avenues for cancer therapy. We are currently focusing our efforts on vesicular stomatitis virus, a simple RNA virus with a natural tropism towards cancer cells.

Ministerio de Ciencia, Innovación y Universidades

Start date: January / 2018.

End date: December / 2020.

Principal investigators:

Rafael Sanjuán


Funding agencies:

Ministerio de Ciencia, Innovación y Universidades


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