A more sensitive and selective piece of equipment, faster in carrying out analysis and a solid service improver for the analysis of trace-level samples (pico-nanograms levels) of a great metabolite number in complex matrices such as biofluids and tissues, in an automated and relatively fast manner, generating a profile by multivariate statistical techniques, etc.

The Triple Quad 6500+ System is a mass spectrometer designed for LC-MS/MS analysis with triple quadrupole technology and linear ion trap, which allows to work in triple quadrupole mode with all of its typical scanning types, with great selectiveness, etc. It additionally enables work in ion trap mode or in combined quadrupole mode with trap, adding new scanning types, increasing versatility, sensitivity, resolution and mass accuracy.

The IonDrive multi-component technology provides benefits to product ions in both their focalisation and transmission, as in sensitivity, robustness and dynamic range limits.

The mass spectrometer has certain characteristics worth highlighting:

• MRM sensitivity in positive mode: 1pg of reserpine
• MRM sensitivity in negative mode: 1pg of chloramphenicol
• Acquisition speed: 500 MRM/sec
• Mass range: 5-2000 m/z
• Detector: Ion drive High Energy
• Dynamic range: 6 orders of magnitude
• Source: DuoSpray ion source (combines ESI/APCI)

The ExionLC AD ultra-high-pressure liquid chromatography system features:

• Micro-volume dual piston pumps.
• Pumping methods: constant flow and pressure, high-pressure gradient system
• Working pressure limitation system
• Accurate pressure measurement
• Automatic piston cleaning system
• Pump leak detector
• Autosampler (bewteen 4 and 40ºC) for both 1.5 ml vials and plates of 96 or 384 positions.
• Volume precision, RSD ≤0.25%
• Volume accuracy: ±1%
• Cross contamination: 0.0015% maximum
• Suction speed: 0.1-15 µl/sec
• Maximum pressure: 1300 bar