GIUV2016-289
The main objective of our research group is to investigate the structural plasticity of the adult brain. We analyze this process at the level of synaptic reorganization, neurite and spine remodeling and neuronal production/incorporation. We are particularly interested in how this structural plasticity is involved in psychiatric disorders, such as schizophrenia and major depression and their treatment. To achieve this objective, we use animal models of these disorders and postmortem material from psychiatric patients. We use different strains of mice expressing fluorescent proteins in selected neuronal populations to visualize structural remodeling, both in fixed tissue and in real time, using organotypic cultures and cerebral windows.
- Estudi de la plasticitat del sistema nervios adult
- Neuroplasticity.Study of the plasticity of the adult nervous system. Study of the estructural plasticity of interneurons in the adult brain and the role of polisialyc acid in this plasticity, the microcircuitry of the olfactory bulb and the hippocampus, both in control and in pathological (Down Syndrome, epilepsy) conditions.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| JUAN NACHER ROSELLO | Director | Universitat de València | |
| Research team | |||
| JOSE MIGUEL BLASCO IBAÑEZ | Member | Universitat de València | |
| EMILIO VAREA LOPEZ | Member | Universitat de València | |
| CARLOS CRESPO RUPEREZ | Member | Universitat de València | |
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- ERI Biotechnology and Biomedicine (BIOTECMED)
- Plasticidad, Interneurona, neurogenesis adulta, bulbo olfatorio, Down, epilepsia
