Grups d'Investigació

GIUV2016-319

The mission of the Reproductive Medicine research group is: to advance the understanding of the processes associated with human reproduction for translational application, improving the efficiency of assisted reproduction treatments and maternal-fetal health. We follow a particular focus on the fields of regenerative medicine related to endometrial and genomic studies on embryo viability and endometrial receptivity, as well as other factors causing infertility.

http://www.incliva.es/investigacion/areas/reproductiva

• Celulas madre adultas en el endometrio humano
• Estudio de la receptividad endometrial y mapa celular del utero humano
• Estudio de la viabilidad embrionaria
• Diagnostico molecular de miomas y leiomiosarcomas
• Estudio de la contribucion materna en el origen de la preeclampsia.
• Estudio de los mecanismos de comunicacion materno-fetal previos a la implantacion embrionaria
• Estudio del microbioma endometrial en la reproduccion humana

• The uterus is the organ that will house the pregnancy and the tissue that covers it, called the endometrium, is responsible for the initiation and maintenance of pregnancy. Currently, there is no cure for clinical situations resulting from the destruction of endometrial tissue or the absence of a functional uterus. Our research group has demonstrated the existence of a specialised population of endometrial somatic stem cells. Our aim is to apply this knowledge to the reconstruction of the human endometrium in patients with Asherman's syndrome or endometrial atrophy.
• Study of embrionic viability.Today, the only method used to select the most viable embryo with the greatest potential in IVF implantation is based solely on morphological parameters. However, a morphologically normal embryo does not mean that there are no chromosomal abnormalities, in fact, it is estimated that 70% of morphologically normal embryos have aneuploidies. Dr. Simón's group has been researching different state-of-the-art molecular techniques at a genetic, proteomic and metabolomic level, to search for non-invasive markers that allow embryos with high implantation capacity to be differentiated from those with poor prognosis or aneuploid embryos.
• Study of the endometrial receptivity and human uterus cell atlas.Our research group has been a pioneer in establishing a transcriptomic signature of human endometrial receptivity. Recently, we have reached an important milestone by dissecting the multidimensional complexity of endometrial tissue at single-cell resolution (Wang, W., et al., 2020), thus opening a new field of study for the analysis of the changes experienced by the endometrium during the menstrual cycle. Also, through the European HUTER project coordinated by Prof. Simón, we are carrying out the characterisation of uterine cells from the perspective of the cellular profile of the endometrium and myometrium, both in physiological and pathological conditions. To do this, we work collaboratively with experts in characterisation at the single cell level and under the umbrella of the European Commission and the international initiative Human Cell Atlas (HCA).

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• Pediatrics, Obstetrics and Gynaecology

• Células madre somáticas; endometrio humano; medicina reproductiva
• Genómica; proteómica; metabolómica; viabilidad embrionaria
• endometrium; endometrial receptivity, transcriptomics