Grups d'Investigació

GIUV2017-372

Regenerative Medicine Line: Study of cartilage regeneration. Study of bone regeneration. Study of the use of pulp precursors in regenerative therapies. Study of the regeneration of dental and peridental tissues. Study of induction and corneal regeneration. Histopathology line: Study of the extent of myocardial infarction and its determinants. Study of the vascularisation of renal tumours. Study of ciliary pathology.

No Determinada

• Estudio de la integracion y aceptacion Biologica de diferentes sustitutos de Ingenieria tisular. En este sentido realizamos una valoracion Histopatologica de la aceptacion de diferentes sustitutos generados por ingenieria tisular en modelos animales de experimentacion animal incluyendo constructos para la regeneracion de cartilago articular, hueso tejidos dentarios y vias aereas.
• Aislamiento de celulas madre para ingenieria tisular. Buscamos fuentes alternativas de obtencion de precursores utiles para ingenieria tisular. Actualmente estamos trabajando con celulas madre aisladas de pulpa dental, mucosa respiratoria, cartilago articular y tejido adiposo.
• Diseño de hidrogeles como andamiajes para ingenieria tisular. Estudiamos la construccion de diferentes scaffolds utilizando hidrogeles mixtos de alginato/agarosa asociados con precursores condrales y con celulas madre de pulpa dental para la regeneracion de cartilago hialino.
• Testado in vitro de nuevos biomateriales y/o procesos de produccion de scaffolds para ingenieria tisular y testado in vitro de adhesion, proliferacion y citotoxicidad para aplicaciones posteriores desarrolladas in vivo.
• Regeneracion de via aerea mediante matrices descelularizadas. Evaluamos diferentes sistemas de descelularizacion, recelularizacion y esterilizacion de traqueas para su uso como sustitutos traqueales in vivo.
• Diseño de protesis traqueales mediante impresion 3D. Estudiamos diferentes materiales, porosidades y sistemas de asociacion con hidrogeles para su potencial usos como sustitutos artificiales de traqueas.

• Study of cartilage regeneration.Tissue engineering applied to the osteoarticular system. We evaluate different biomaterials for their application to articular cartilage regeneration. We have evaluated substitutes based on chitosan discs, PCL and hyaluronic acid, as well as other elements including mixed hydrogels and microspheres both in vitro and in vivo. This line of research has been funded by the ministry without interruption since 2004 (MAT2004-04980, MAT2007-66759, MAT2013-46467-C4-4-R and MAT2016-76039-C4-2-R).
• Study of the regeneration of dental and peridental tissues.We test different materials including titanium prostheses or decellularised dental matrices for the regeneration of dental and peridental tissues. We also evaluate connective tissues such as dental pulp or periodontal ligament as sources of stem cells with different potentials. This line is funded by different projects financed in competitive public calls including IMPORTOX or NerBIO.
• Study of the extent of myocardial infarction and its determinants.Study of the extent of myocardial infarction and its determining factors. In this line, we work on the histopathological evaluation of myocardial infarction from a morphometric approach, assessing distortion at the level of cellular and conjunctive elements of the cardiac wall.
• Airway tissue engineering.Airway tissue engineering. We work on designing tissue engineered substitutes for tracheal and bronchial prostheses including PCL constructs, hyaluronic acid, combined PLA scaffolds and alginate/agarose hydrogels and decellularised tissue matrices. This line of research is funded by the Carlos III Health Institute through grant PI16/01315.
• Cilia and ciliopathies.Cilia and ciliopathies. We evaluate the ultrastructure of the ciliary apparatus in patients diagnosed with CPD and other ciliopathies by combining diagnostic support techniques such as high-definition video capture and molecular biology marker analysis. This line has been funded by the Carlos III Health Institute through different grants (PI06/60726, PI16/01315).
• Study of corneal induction and regeneration.Study of corneal induction and regeneration.

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• Pathology

• articular cartilage, chondrocytes, chondral injuries, regenerative medicine
• Celulas madre pulpa dental,implantes titanio, regeneración ósea
• histopathology, myocardium, infarction, extracellular matrix
• airways, regeneration, respiratory mucosa
• cilia, ciliopathies, primary ciliary dyskinesia, respiratory mucosa
• regeneracion corneal, ingeniería tisular