GIUV2017-383
GRELCA is a multidisciplinary research group located in the Departments of Medicine and Physiology of the Faculty of Medicine and Dentistry of the University of Valencia, led by Dr. Luis Such Belenguer, Emeritus Professor of the Department of Physiology, Dr. Francisco Javier Chorro Gascó, Head of the Cardiology Department of the Hospital Clínico Universitario and Professor of the Department of Medicine of the aforementioned University, who has extensive experience in the field of experimental cardiac electrophysiology. It is directed by Dr. Antonio Alberola Aguilar, Professor of the Department of Physiology at the University of Valencia. It includes researchers from the Research Institute of the Hospital Clínico Universitario de Valencia (INCLIVA) and from the departments of Medicine, Physiology, Nursing, Physiotherapy and Electronic Engineering. The group also has collaborating laboratories at the ITACA institute, which belongs to the Polytechnic City of Innovation, a science park of the Polytechnic University of Valencia, where close scientific collaboration with specialists in technical areas (Telecommunications Engineers, Electronic Engineers, specialists in digital signal...GRELCA is a multidisciplinary research group located in the Departments of Medicine and Physiology of the Faculty of Medicine and Dentistry of the University of Valencia, led by Dr. Luis Such Belenguer, Emeritus Professor of the Department of Physiology, Dr. Francisco Javier Chorro Gascó, Head of the Cardiology Department of the Hospital Clínico Universitario and Professor of the Department of Medicine of the aforementioned University, who has extensive experience in the field of experimental cardiac electrophysiology. It is directed by Dr. Antonio Alberola Aguilar, Professor of the Department of Physiology at the University of Valencia. It includes researchers from the Research Institute of the Hospital Clínico Universitario de Valencia (INCLIVA) and from the departments of Medicine, Physiology, Nursing, Physiotherapy and Electronic Engineering. The group also has collaborating laboratories at the ITACA institute, which belongs to the Polytechnic City of Innovation, a science park of the Polytechnic University of Valencia, where close scientific collaboration with specialists in technical areas (Telecommunications Engineers, Electronic Engineers, specialists in digital signal processing and analysis, etc.) is materialised for the development of cardiac electrical activity mapping systems and the experimental equipment necessary for the evolution of the discipline, which has been in existence for more than 20 years. The complementary nature of the researchers in the group provides the framework from which to approach the study of the mechanisms involved in the onset, perpetuation and cessation of cardiac rhythm disorders, especially fibrillatory processes, with the aim of developing analysis procedures, diagnostic techniques and therapeutic alternatives in relation to arrhythmias and sudden cardiac death. Our research has been directed especially towards the study of the mechanisms that regulate fibrillatory processes, both atrial and ventricular, using cartographic and spectral techniques. We are particularly interested in the analysis of proarrhythmogenic electrophysiological changes induced by ventricular mechanical stretch and the identification of pharmacological agents that counteract these effects, the study of myocardial protection derived from regular physical exercise and the analysis of the electrophysiological changes produced during ischaemic processes. Two new lines of research have recently been initiated: the implementation of a chronic infarction model to study the relationship between the characteristics of ischaemia-reperfusion injury and the inducibility and maintenance of malignant ventricular arrhythmias, and the development of an animal model of metabolic syndrome to study the impact of the combination of the different manifestations of the disease on cardiac electrical remodelling and its potential arrhythmogenic mechanisms.
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- Estudio de las propiedades electrofisiologicas que afectan a los procesos implicados en el inicio, perpetuacion y cese de las arritmias cardiacas
- Estudio del papel de la homeostasis del calcio en la arritmogenesis y de los efectos de farmacos que actuan sobre la dinamica intracelular de calcio
- Analisis de los cambios electrofisiologicos arritmogenicos inducidos por el estiramiento mecanico ventricular
- Analisis de los efectos electrofisiologicos protectores del ejercicio fisico en relacion con la induccion, mantenimiento y cese de arritmias cardiacas
- Mecanismos de proteccion frente al daño miocardico por isquemia-reperfusion y frente a los efectos proarritmogenos del remodelado post-infarto
- Experimental studies for the analysis of electrophysiological parameters linked to the establishment, maintenance and cessation of ventricular fibrillation.Analysis of the electrophysiological properties affecting the processes involved in the onset, perpetuation and cessation of VF, an arrhythmia responsible for about 80% of all sudden cardiac deaths, the underlying mechanisms of which remain incompletely understood.
- Role of calcium homeostasis in arrhythmogenesis. Study of the electrophysiological effects of drugs that act on intracellular calcium dynamics..Analysis of the effects of alterations in calcium homeostasis on arrhythmogenesis. Search for and study of the electrophysiological effects of drugs that act on intracellular calcium dynamics.
- Analysis of the arrhythmogenic electrophysiological changes induced by ventricular mechanical stretch..Ventricular stretch, a pathophysiological condition present in situations involving pressure or volume overload of the cardiac chambers, generates proarrhythmogenic electrophysiological alterations. Search for and identification of pharmacological agents that counteract these effects.
- Basic mechanisms, diagnosis, prediction and prevention of cardiac damage in reperfused acute myocardial infarction..To advance methods of diagnosis and prevention of myocardial damage after acute myocardial infarction. The group will conduct an experimental analysis of the relationship between the characteristics of ischaemia-reperfusion injury and the inducibility and maintenance of ventricular arrhythmias.
- Analysis of protective electrophysiological effects of physical exercise in relation to the induction, maintenance and cessation of cardiac arrhythmia..Study of the protective electrophysiological effects of chronic physical exercise: influence of the autonomic nervous system and mitochondrial oxidative stress. Analysis of the effects on electrophysiological changes induced by myocardial ischaemia in relation to IKATP current.
- Effects of histone deacetylation inhibition on post-infarct remodelling of arrhythmogenic substrate.Ischaemia/reperfusion damage promotes pro-arrhythmogenic ventricular remodelling. The effects of histone deacetylase (DHA) enzyme inhibition on this process and its impact on electrophysiological properties and arrhythmogenesis will be discussed.
- Development of an animal model of metabolic syndrome and study of possible cardiac electrical remodeling associated..Development of an animal model (New Zealand white rabbits) of metabolic syndrome and study of the impact of the combination of the different manifestations of the disease on cardiac electrical remodelling and its potential arrhythmogenic mechanisms.
- Development of tools for the recording and analysis of cardiac electrophysiological signals: multielectrode devices and optical mapping Systems..Development, updating and integration of tools for the recording, processing and analysis of cardiac electrophysiological signals based on multi-electrode devices and optical mapping systems (voltage and calcium signal analysis).
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| ANTONIO M ALBEROLA AGUILAR | Director | Universitat de València | |
| Research team | |||
| FRANCISCO JAVIER CHORRO GASCO | Member | Universitat de València | |
| LUIS SUCH MIQUEL | Member | Universitat de València | |
| MARIA DOLORES MAURICIO AVIÑO | Member | Universitat de València | |
| JOAQUIM CANOVES I FEMENIA | Member | Universitat de València | |
| GERMAN PARRA GIRALDO | Member | Universitat de València | |
| MANUEL ZARZOSO MUÑOZ | Member | Universitat de València | |
| MARIA ISABEL TRAPERO GIMENO | Collaborator | Universitat de València | |
| LUIS JOAQUIN MAINAR LATORRE | Collaborator | Universidad CEU Cardenal Herrera | adjunct professor |
| IRENE DEL CANTO SERRANO | Collaborator | Universitat de València | |
| ÓSCAR JULIÁN ARIAS MUTIS | Collaborator | Universitat de València | |
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- Physiology
- Isquemia/reperfusión; Remodelado cardiaco; Fibrosis; Electrofisiología; Arritmogénesis; DAH
- Síndrome metabólico; Remodelado cardiaco; Fibrosis; Arritmogénesis
- Análisis de señales; Electrofisiología cardiaca; Dispositivos multielectrodo,
- Fibrilación ventricular; Muerte súbita cardiaca; Electrofisiología cardiaca; Arritmias; Fisiopatología
- Homeostasis calcio; Electrofisiología cardiaca; Arritmogénesis; Fármacos
- Estiramiento ventricular; Electrofisiología; Arritmogénesis; Agentes farmacológicos
- Infarto agudo de miocardio;isquemia;reperfusión;daño miocárdico;arritmogénesis;fibrosis
- Ejercicio físico; Electrofisiología cardiaca; Isquemia; Protección miocárdica; Arritmias; IKATP; SNA; Estrés oxidativo.
