GIUV2013-052
In our group we design and synthesize ligands derived from the triazole ring and sulfonamide-type ligands, with which coordination compounds with different metal ions of biological interest [Cu(II), Zn(II), Fe(II,III),...] are prepared. The compounds are structurally and spectroscopically characterised. In a second stage, the interaction of the obtained complexes with DNA is studied, and their nuclease activity is tested with and without activating agents. In a new and current approach, the activity of the metallo-nucleases synthesised in combination with QDs (quantum dots) is studied, with the aim of achieving an enhancement and/or activation of their nucleolytic properties. The effect of photoactivation (with harmless light) on the compounds and on the nuclease-QDs systems is also investigated. Finally, the most active systems are tested in vivo on tumour cell lines. In parallel, the magnetic properties of the polynuclear compounds obtained are studied. In the case of cyclic trinuclear compounds, examples of spin-frustrated systems, a more exhaustive antisymmetric exchange study is carried out.
- Synthesize new compounds capable of selectively recognizing DNA by mimicking the DNA-protein bond
- Obtain new oxidative and/or hydrolytic nucleases; enhance the activity of metallonucleases by combining them with QDs (quantum dots)
- Testing the most active compounds on tumor cell lines in order to obtain alternative chemotherapy drugs
- Evaluate the potential photoactivation of QDs-metallonuclease systems in search of a new generation of drugs for photodynamic therapy
- Obtain compounds with magnetic properties that are relevant because they are unusual and/or because they exhibit the antisymmetric exchange phenomenon
- Chemical Nucleases based on Coordination Compounds.Our research basically consists of the preparation and characterisation of new oxidative and/or hydrolytic metallo-nucleases, mainly based on metal ion coordination compounds of biological interest with triazole-type ligands and sulfonamide-type ligands.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| SACRAMENTO FERRER LLUSAR | Director | Universitat de València | |
| Research team | |||
| M GLORIA ALZUET PIÑA | Member | Universitat de València | |
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- Inorganic Chemistry
- QUANTUM DOT
- NUCLEASE
- DNA INTERACTION
- COORDINATION COMPOUND
- TRIAZOLE
- SULFONAMIDE
- MAGNETISM
- ANTISYMMETRIC SWAPPING
- COPPER
