GIUV2013-052

In our group we design and synthesize ligands derived from the triazole ring and sulfonamide-type ligands, with which coordination compounds with different metal ions of biological interest [Cu(II), Zn(II), Fe(II,III),...] are prepared. The compounds are structurally and spectroscopically characterised. In a second stage, the interaction of the obtained complexes with DNA is studied, and their nuclease activity is tested with and without activating agents. In a new and current approach, the activity of the metallo-nucleases synthesised in combination with QDs (quantum dots) is studied, with the aim of achieving an enhancement and/or activation of their nucleolytic properties. The effect of photoactivation (with harmless light) on the compounds and on the nuclease-QDs systems is also investigated. Finally, the most active systems are tested in vivo on tumour cell lines. In parallel, the magnetic properties of the polynuclear compounds obtained are studied. In the case of cyclic trinuclear compounds, examples of spin-frustrated systems, a more exhaustive antisymmetric exchange study is carried out.

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• Sintetizar nuevos compuestos capaces de reconocer selectivamente al ADN mimetizando el enlace ADN-proteína
• Obtener nuevas nucleasas oxidativas y/o hidrolíticas; potenciar la actividad de las metalo nucleasas mediante la combinación con QDs (quantum dots)
• Ensayar los compuestos más activos sobre líneas celulares tumorales con el fin de obtener fármacos alternativos en quimioterapia
• Evaluar la posible fotoactivación de los sistemas QDs-metalo nucleasas buscando una nueva generación de fármacos para terapia fotodinámica
• Obtener compuestos con propiedades magnéticas relevantes por inusuales y/o por presentar el fenómeno de canje antisimétrico

• Chemical Nucleases based on Coordination Compounds.Our research basically consists of the preparation and characterisation of new oxidative and/or hydrolytic metallo-nucleases, mainly based on metal ion coordination compounds of biological interest with triazole-type ligands and sulfonamide-type ligands.

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• Inorganic Chemistry