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Microecology of the Respiratory Tract - MicroResp

Reference of the Group:

GIUV2026-006

 
Description of research activity:
The research activity of MicroResp is focused on understanding the ecological and evolutionary relationships between microorganisms of the respiratory tract and their host. The different populations that coexist within human in this restrictive niche (mainly prokaryotes, viruses and fungi) comprise a complex dynamic system of direct and indirect interactions, mediated by proteins, metabolites or extracellular vesicles. Also, the genomes of the species that comprise it do not remain undisturbed, but rather there is an exchange of genetic material that catalyses evolutionary processes, with the exchange of plasmids, mobile islands, incorporation of exogenous DNA, transduction by phages, transposons, etc. From the group's clinical perspective, understanding the healthy respiratory tract system serves as a reference for the study of infectious processes and pathogenesis mechanisms, the emergence of resistances, vaccine evasion, and dysbiotic states of the respiratory microbiota. The methodological approach includes in silico and in vitro analysis, multi-omics techniques, molecular evolution, phylogenetics, obtaining protein-protein interaction networks, and experimentation aimed at...The research activity of MicroResp is focused on understanding the ecological and evolutionary relationships between microorganisms of the respiratory tract and their host. The different populations that coexist within human in this restrictive niche (mainly prokaryotes, viruses and fungi) comprise a complex dynamic system of direct and indirect interactions, mediated by proteins, metabolites or extracellular vesicles. Also, the genomes of the species that comprise it do not remain undisturbed, but rather there is an exchange of genetic material that catalyses evolutionary processes, with the exchange of plasmids, mobile islands, incorporation of exogenous DNA, transduction by phages, transposons, etc. From the group's clinical perspective, understanding the healthy respiratory tract system serves as a reference for the study of infectious processes and pathogenesis mechanisms, the emergence of resistances, vaccine evasion, and dysbiotic states of the respiratory microbiota. The methodological approach includes in silico and in vitro analysis, multi-omics techniques, molecular evolution, phylogenetics, obtaining protein-protein interaction networks, and experimentation aimed at testing hypotheses.
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Web:

(sin web)

 
Scientific-technical goals:
  • Estudiar el papel del mobiloma en la evolución de la microbiota respiratoria
  • Describir y comprender el sistema de comunicación microbiota-microbiota y microbiota-huésped
  • Comprobación experimental y/o in silico de hipótesis e interacciones de interés
  • Transferencia del conocimiento con aplicación clínica
  • Describir y comprender el sistema de comunicación microbiota-microbiota y microbiota-huésped
 
Research lines:
  • Dynamics of the respiratory microbiota.Study of the ecological relationships and dynamics of the respiratory microbiota through the analysis of population composition, the observation of patterns, and in silico and in vitro experimentation.
  • Respiratory proteome and interactome.Study of the microbiota-microbiota and microbiota-host communication systems, using in silico and in vitro techniques.
  • Respiratory mobilome and populations evolution.Identification of mobile genetic elements in the respiratory microbiome. Studies of molecular evolution and phylogenetics.
  • Transference and clinical application.Identification of biomarkers and development of molecular diagnostic methods.
 
Group members:
Name Nature of participation Entity Description
ANA VALERO RELLODirectorUniversitat de València
 
CNAE:
  • -
 
Associated structure:
  • Microbiology and Ecology
 
Keywords:
  • PRECLINICAL STUDIES
  • PHARMACOLOGY
  • VIRUSES
  • INFECTIONS
  • OUTBREAKS
  • MOLECULAR MARKERS
  • GENETIC DIVERSITY
  • EPIDEMIOLOGICAL SURVEILLANCE
  • POPULATION GENETICS
  • MOLECULAR BIOINTERACTION MODELS
  • ECOLOGY OF COMMUNITIE
  • BACTERIA
  • MICROBIOME
  • PHYLOGENETIC TREES
  • KNOWLEDGE TRANSFER
  • LUNG
  • ASTHMA
  • PHARMACOLOGICAL TARGET
  • COPD
  • FPI
  • PULMONARY HYPERTENSION
  • CHRONIC RHINOSINUSITIS
  • RESEARCH AGENDA
  • OPEN INNOVATION IN SCIENCE
  • SCIENCE-SOCIETY INTERACTIONS
  • RESEARCH PRACTICES