GIUV2026-023
Our research activity focuses on the study of the cellular, molecular, and vascular processes involved in brain damage caused by stroke, with a translational approach aimed both at understanding the pathophysiology of cerebral ischemia and at developing new therapeutic strategies. The groups work addresses the analysis of the cascade of brain injury, neuroprotective processes, the search for therapies for stroke treatment, and the identification of peripheral biomarkers to improve diagnosis, stratification, and patient follow-up. All of this is pursued with the ultimate goal of identifying new therapeutic targets capable of protecting or repairing brain tissue after ischemic stroke and of contributing to improved functional outcomes for affected individuals. The groups main lines of research focus on evaluating, using animal models, the neuroprotective capacity of endogenous and exogenous substances, particularly Selective Estrogen Receptor Modulators (SERMs). In addition, the role of inflammation in cerebral ischemic pathology is studied, as well as cellular senescence as a potential therapeutic target in ischemic stroke through multi-omic approaches. This strategy opens the door...Our research activity focuses on the study of the cellular, molecular, and vascular processes involved in brain damage caused by stroke, with a translational approach aimed both at understanding the pathophysiology of cerebral ischemia and at developing new therapeutic strategies. The groups work addresses the analysis of the cascade of brain injury, neuroprotective processes, the search for therapies for stroke treatment, and the identification of peripheral biomarkers to improve diagnosis, stratification, and patient follow-up. All of this is pursued with the ultimate goal of identifying new therapeutic targets capable of protecting or repairing brain tissue after ischemic stroke and of contributing to improved functional outcomes for affected individuals. The groups main lines of research focus on evaluating, using animal models, the neuroprotective capacity of endogenous and exogenous substances, particularly Selective Estrogen Receptor Modulators (SERMs). In addition, the role of inflammation in cerebral ischemic pathology is studied, as well as cellular senescence as a potential therapeutic target in ischemic stroke through multi-omic approaches. This strategy opens the door to the development of senotherapeutic therapies as new tools for the treatment of this condition.
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- Desarrollo y evaluación de estrategias neuroprotectoras y neuroreparadoras en modelos animales de ictus
- Caracterización multiómica de procesos patológicos asociados al ictus.
- Estudio de la senescencia celular como posible diana terapéutica en el ictus y desarrollo de terapias senoterapéuticas.
- Identificación de biomarcadores periféricos que mejoren el diagnóstico, la estratificación y el seguimiento de pacientes con ictus.
- Estudio de los procesos celulares, moleculares y vasculares implicados en el daño cerebral tras el ictus.
- Study of cellular and molecular mechanisms in cerebral ischemic pathophysiology.This line of research focuses on understanding the cellular and molecular processes that occur after an ischemic stroke, with the aim of identifying the mechanisms that contribute to neuronal damage, with special emphasis on neuroinflammatory processes and on the activation of associated pathological pathways.
- Preclinical evaluation of neuroprotective strategies in stroke using animal models.This line of research focuses on the development and validation of neuroprotective drugs or therapies using animal models. Through these models, interventions capable of modulating the cellular and molecular mechanisms involved in post-stroke brain damage are investigated, contributing to a deeper understanding of stroke pathophysiology, as well as to the assessment of the biological impact of experimental therapies.
- Multi-omic studies and search for plasma biomarkers of stroke.This line focuses on the use of multi-omic approaches (epigenomics, transcriptomics, and proteomics) for the study of stroke and the identification of peripheral biomarkers that can improve both diagnosis and the monitoring of therapeutic interventions. In particular, our aim is to characterize stroke-induced cellular senescence in order to understand its role in the progression of cerebral ischemic injury and to explore its potential as a target for the development of effective senotherapeutic strategies for the treatment of ischemic stroke.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| MARÍA CASTELLO RUIZ | Director | Universitat de València | |
| Research team | |||
| ALICIA ALIENA VALERO | Member | Universitat de València | |
| IRENE MARÍA ESCUDERO MARTÍNEZ | Collaborator | Hospital Universitari i Politècnic La Fe | Phisician |
- Cellular Biology and Functional Biology
- NEUROPROTECTION
- ISCHAEMIC STROKE
- NEURAL REPAIR
- CEREBRAL PATHOPYSIOLOGY
