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Tuberculosis is, after COVID-19, the infectious disease that kills the most people in the world, and although it has been known for thousands of years, we still do not know some key aspects of the infection.
Acronym

mol-TB-host

Description

Title: Molecular mechanisms involved in the pathogenic differences in favourable and non-favourable combinations of M. tuberculosis and the host.

Research Group: PatoGenOmica Bacteriana

One of this aspects is that it establishes the pathogenic difference in distinct infections. In the previous project we have proved through an experiment in vitro that the interaction between specific genetic contexts of pathogen-host gives as a result different virulence phenotypes. The favourable infections, where bacteria and hosts are more compatible, are more virulent because they produce a higher rate of infection and a higher cell death. In addition, we describe different expression patterns in differential ecotype genes. Our next objective is to give a step forward and characterising molecularly the difference in favourable and unfavourable infections, through experiments and omic data analysis.

Ministerio de Ciencia e Innovación - Fondos FEDER - Agencia Estatal de Investigación

Developers of the project
Institut de Biologia Integrativa de Sistemes (I2SYSBIO)

i2sysbio.uv.es

iu.i2sysbio@uv.es

Start date
2021 September
End date
2025 August
Funding agencies:

PID2021-123443OB-I00 Project supported by MCIN/AEI/10.13039/501100011033/ and by FEDER Una manera de hacer Europa.