GIUV2023-541
The Virus Evolution Group of the University of Valencia, attached to the Institute for Integrative Systems Biology (I2SysBio) develops its research activity in the following areas: determinants of virus evolution and diversification, identification of new mammalian and human viruses and study of their diversity, analysis of the zoonotic potential of animal viruses and characterisation of viral transmission mechanisms. Likewise, the group addresses applied issues such as the discovery of new antiviral compounds, validation of the virucidal effect of materials of industrial interest, identification of new genes with antiviral potential, evolution of oncolytic viruses, waste-water based viral epidemiology. The viruses on which these investigations focus are mainly the following: laboratory model viruses such as vesicular stomatitis virus or others (bacteriophages, baculoviruses, enteroviruses), model coronavirus and SARS-CoV-2 and viral envelopes belonging to . The approaches employed by the group are both experimental and computational and include: - Experimental evolution under controlled laboratory conditions - Analysis of viral efficacy in cell cultures using automated techniques...The Virus Evolution Group of the University of Valencia, attached to the Institute for Integrative Systems Biology (I2SysBio) develops its research activity in the following areas: determinants of virus evolution and diversification, identification of new mammalian and human viruses and study of their diversity, analysis of the zoonotic potential of animal viruses and characterisation of viral transmission mechanisms. Likewise, the group addresses applied issues such as the discovery of new antiviral compounds, validation of the virucidal effect of materials of industrial interest, identification of new genes with antiviral potential, evolution of oncolytic viruses, waste-water based viral epidemiology. The viruses on which these investigations focus are mainly the following: laboratory model viruses such as vesicular stomatitis virus or others (bacteriophages, baculoviruses, enteroviruses), model coronavirus and SARS-CoV-2 and viral envelopes belonging to . The approaches employed by the group are both experimental and computational and include: - Experimental evolution under controlled laboratory conditions - Analysis of viral efficacy in cell cultures using automated techniques - Field techniques and use of biological materials for virus discovery - Gene synthesis and reconstruction of viral envelopes using pseudoviruses - Viral metagenomics (viromics), high-throughput sequencing and transcriptomics - Virus detection and quantification by qPCR - Molecular phylogenetics, molecular evolution and population genetics - Meta-analysis of factors involved in virus infectivity - Bioinformatics, mathematical modelling and simulations
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- Comprender la evolucion viral
- Descubrimiento de virus
- Identificar virus con riesgo zoonotico
- Identificar factores clave en la transmision viral
- Descubrimiento de nuevos antivirales y otras aplicaciones en virologia
- Experimental evolution for assessing disease emergence risks.We research receptor-dependent cellular tropism of enveloped RNA viruses, a key process in the emergence of new human viruses. For this purpose, gene synthesis, pseudoviruses, sequencing and genetic functional analysis are used.
- Viral zoonoses: viromics, evolution and experimental analysis.Research into the presence of viruses with zoonotic potential in our environment is carried out through the viromics of bat and rodent feces and the subsequent functional analysis of the viruses found.
- Wastewater-based viral epidemiology.Wastewater from our environment is analysed for the detection and quantification of circulating human viruses in the context of the current COVID-19 pandemic.
- Directed evolution of oncolytic viruses.Research is carried out on the appearance of cellular resistance to oncolytic viruses and the ability to overcome this resistance. The cellular resistance mechanisms found may have applications beyond oncolytic viruses by also conferring resistance to other non-attenuated viruses.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| RAFAEL SANJUAN VERDEGUER | Director | Universitat de València | |
| Research team | |||
| JEREMY DUFLOO - | Member | Universitat de València | |
| MARC CARRASCOSA SAEZ | Member | Universitat de València | |
| JORGE MORENO GARCIA | Member | Universitat de València | |
| JOSE MANUEL CUEVAS TORRIJOS | Collaborator | Universitat de València | |
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- Zoonosis; emergencia viral; evolución experimental; tropismo viral
- Zoonosis; diversidad viral; virómica
- Aguas residuales; SARS-CoV-2; qPCR; epidemiología
- Respuesta antiviral; viroterapia; evolución dirigida
