GIUV2023-595
Our research group is attached to the Department of Biochemistry and Molecular Biology of the University of Valencia (Medicine Section) and has been part of IIS INCLIVA (Biomedical Reasearch Institute) since its creation. In addition, it continuously collaborates with the Department of Physiology and Biophysics at The Chicago Medical School, USA, where the group's coordinator has been appointed as a research professor for more than twenty years. Dr. Juan R Viña's research career is extensive, encompassing the study of metabolism and its contribution to various pathological and physiological processes, such as the flow of nutrients between tissues and tissue adaptation to physiological conditions (fasting and lactation) and transport across the blood-brain barrier. Although the research profile of the group corresponds mainly to the area of biochemistry and molecular biology, its areas of interest also include endocrinology, metabolism, cell biology, nutrition and dietetics, anatomy, morphology, gastroenterology and pharmacology. The group's different lines of research have been aimed at an integrated understanding of the molecular mechanisms underlying pathophysiological processes...Our research group is attached to the Department of Biochemistry and Molecular Biology of the University of Valencia (Medicine Section) and has been part of IIS INCLIVA (Biomedical Reasearch Institute) since its creation. In addition, it continuously collaborates with the Department of Physiology and Biophysics at The Chicago Medical School, USA, where the group's coordinator has been appointed as a research professor for more than twenty years. Dr. Juan R Viña's research career is extensive, encompassing the study of metabolism and its contribution to various pathological and physiological processes, such as the flow of nutrients between tissues and tissue adaptation to physiological conditions (fasting and lactation) and transport across the blood-brain barrier. Although the research profile of the group corresponds mainly to the area of biochemistry and molecular biology, its areas of interest also include endocrinology, metabolism, cell biology, nutrition and dietetics, anatomy, morphology, gastroenterology and pharmacology. The group's different lines of research have been aimed at an integrated understanding of the molecular mechanisms underlying pathophysiological processes in animal models or cells in culture. Selecting different tissues such as the lung, liver or mammary gland as experimental models, the group has focused on the study of the inflammatory response, cell proliferation, cell death, signalling networks, transcriptional regulatory nodes and epigenetics that will eventually lead to the propagation and resolution of a certain response to a physiological or pathological stimulus.
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- Obtener una vision integrada de nodos de regulacion en diferentes tejidos
- Study of the pregnancy/lactation cycle of the mammary gland.Within this line, the main objective is to understand the programmed cell death and tissue remodelling of the mammary gland after the pregnancy/lactation cycle and to study breast cancer associated with this cycle.
- Study of the blood brain barrier (BBB).Study of the blood-brain barrier, focusing on the different amino acid transporters that can be found on both sides of it.
- Molecular study of liver pathophysiology.Molecular study of different liver disorders: fibrosis, SAMe homeostasis, non-alcoholic steatohepatitis, alcoholic and non-alcoholic liver cirrhosis and hepatocellular carcinoma (HCC)
- Tissue biochemistry of the respiratory system.This group studies the mechanisms that control respiratory homeostasis, as well as the dysregulation of molecular and cellular pathways in respiratory pathological processes, such as allergic inflammation or pulmonary fibrosis.
- Study of tissue alterations produced by vitamin A deficiency.Vitamin A deficiency affects several tissues, including the lungs and liver. We aim to study the alteration of the extracellular matrix in models with chronic deficiency.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| JUAN VIÑA RIBES | Director | Universitat de València | |
| Research team | |||
| M TERESA BARBER SANCHIS | Member | Universitat de València | |
| ROSA ZARAGOZA COLOM | Member | Universitat de València | |
| ELENA RUIZ GARCIA-TREVIJANO | Member | Universitat de València | |
| ELENA ORTIZ ZAPATER | Member | Universitat de València | |
| AMPARO GIMENO MONROS | Collaborator | Universitat de València | |
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- Involución; glándula mamaria; embarazo; calpaínas; inflamación; cáncer de mama
- Transportadores de aminoácidos; luminal; abluminal; barrera hematoencefálica; transporte activo
- hígado; fibrosis; inflamación; regeneración hepática
- Fibrosis pulmonar; modelos 3D; metabolismo
- Retinol; Fibrosis; Vitamina A; RAR; matriz extracelular; inflamación; EMT
