Grups d'Investigació

GIUV2025-663

The Perinatal Physiology and Pathophysiology Research Group is composed of a multidisciplinary team of researchers, including physicians, pharmacists, dentists, nutritionists, and engineers, with the aim of advancing knowledge on the fetal-to-neonatal transition and subsequent adaptation. The group's main research area focuses on the perinatal period, particularly on the physiological and pathophysiological changes that occur during the transition from fetal to neonatal life. This group investigates the toxic effects of oxygen on the central nervous system when administered during the postnatal adaptation period, especially in preterm newborns. Their approach includes the assessment of oxidative stress, neurological damage, and inflammation associated with this intervention.

No Determinada

• Validacion de nuevos biomarcadores geneticos y/o metabolomicos que reflejen la neuroinflamacion y/o daño oxidativo cerebral en prematuros
• Nuevas terapias de reoxigenacion en la reanimacion postnatal en los recien nacidos prematuros

• Animal model of neonatal hypoxia and reoxygenation.Experimental model in newborn mice with perinatal asphyxia in which brain damage is assessed and genetic and metabolic biomarkers are sought.
• Pregnant mouse model with delivery in hypoxia and subsequent reoxygenation.New experimental model of foetal-neonatal transition in mice to study the effect of preconditioning hypoxia and/or resuscitation in premature newborns at different oxygen atmospheres at the pre- and postnatal levels in the central nervous system, lungs and heart.
• Animal model of neonatal hypoxic-ischemic encephalopathy..Induction of EHI in newborn mice: assessment of neurological damage and antioxidant therapies
• Premature oxygenation study..Participation in clinical studies on the influence of oxygenation in foetal-neonatal transition, resuscitation and postnatal pathology in premature infants.
• Retinopathy of Prematurity Study.Participation in clinical studies on the search for ROP biomarkers in premature newborns.
• Study of oral health in premature patients..Study of the effect of prematurity in paediatric ADHD patients and its relationship with oral health and treatments

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• Physiology