The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research and Scientific Policies. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: Regenerative Medicine Line: Study of cartilage regeneration. Study of bone regeneration. Study of the use of pulp precursors in regenerative therapies. Study of the regeneration of dental and peridental tissues. Study of induction and corneal regeneration. Histopathology line: Study of the extent of myocardial infarction and its determinants. Study of the vascularisation of renal tumours. Study of ciliary pathology.
Web:
Scientific-technical goals: - Study of the integration and biological adaptation of different tissue engineering substitutes. In this regard, we performed a histopathological assessment of the acceptance of different tissue engineering substitutes in animal models, including constructs for the regeneration of articular cartilage, bone, dental tissues, and airways.
- Stem cell isolation for tissue engineering. We are seeking alternative sources of precursors useful for tissue engineering. We are currently working with stem cells isolated from dental pulp, respiratory mucosa, articular cartilage, and adipose tissue.
- Design of hydrogels as scaffolds for tissue engineering. We studied the construction of different scaffolds using mixed alginate/agarose hydrogels associated with chondral precursors and dental pulp stem cells for hyaline cartilage regeneration.
- In vitro testing of new biomaterials and/or scaffold production processes for tissue engineering and in vitro testing of adhesion, proliferation and cytotoxicity for subsequent applications developed in vivo.
- Airway regeneration using decellularized matrices. We evaluated different systems for decellularization, recellularization, and sterilization of tracheae for use as tracheal substitutes in vivo.
- Design of tracheal prostheses using 3D printing. We studied different materials, porosities, and hydrogel bonding systems for their potential use as artificial tracheal substitutes.
Research lines: - Study of cartilage regeneration.Tissue engineering applied to the osteoarticular system. We evaluate different biomaterials for their application to articular cartilage regeneration. We have evaluated substitutes based on chitosan discs, PCL and hyaluronic acid, as well as other elements including mixed hydrogels and microspheres both in vitro and in vivo. This line of research has been funded by the ministry without interruption since 2004 (MAT2004-04980, MAT2007-66759, MAT2013-46467-C4-4-R and MAT2016-76039-C4-2-R).
- Study of the regeneration of dental and peridental tissues.We test different materials including titanium prostheses or decellularised dental matrices for the regeneration of dental and peridental tissues. We also evaluate connective tissues such as dental pulp or periodontal ligament as sources of stem cells with different potentials. This line is funded by different projects financed in competitive public calls including IMPORTOX or NerBIO.
- Study of the extent of myocardial infarction and its determinants.Study of the extent of myocardial infarction and its determining factors. In this line, we work on the histopathological evaluation of myocardial infarction from a morphometric approach, assessing distortion at the level of cellular and conjunctive elements of the cardiac wall.
- Airway tissue engineering.Airway tissue engineering. We work on designing tissue engineered substitutes for tracheal and bronchial prostheses including PCL constructs, hyaluronic acid, combined PLA scaffolds and alginate/agarose hydrogels and decellularised tissue matrices. This line of research is funded by the Carlos III Health Institute through grant PI16/01315.
- Cilia and ciliopathies.Cilia and ciliopathies. We evaluate the ultrastructure of the ciliary apparatus in patients diagnosed with CPD and other ciliopathies by combining diagnostic support techniques such as high-definition video capture and molecular biology marker analysis. This line has been funded by the Carlos III Health Institute through different grants (PI06/60726, PI16/01315).
- Study of corneal induction and regeneration.Study of corneal induction and regeneration.
Group members:
CNAE:
Associated structure:
Keywords: - NEUROBLASTOMA
- ARTICULAR CARTILAGE
- CHONDROCYTES
- CHONDRAL INJURIES
- REGENERATIVE MEDICINE
- INFARCTION
- EXTRACELLULAR MATRIX
- MYOCARDIUM
- RESPIRATORY MUCOSA
- REGENERATION
- AIRWAYS
- CILIOPATHIES
- CILIA
- PRIMARY CILIARY DYSKINESIA
- DENTAL PULP STEM CELLS
- TITANIUM IMPLANTS
- BONE REGENERATION
- TISSUE ENGINEERING
- CORNEAL REGENERATION
